Results 151 to 160 of about 260,438 (309)

Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases.

open access: yesPharmacology and Therapeutics, 2015
E. Beurel, S. Grieco, R. Jope
semanticscholar   +1 more source

Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury

open access: yesGlia, EarlyView.
Astrocytes play an important role in glaucoma. These cells express Cx43, which can form gap junctions and hemichannels. This study shows that Cx43 deletion in astrocytes provides neuroprotection in glaucoma, possibly through hemichannel activation. ABSTRACT Astrocytes in the retina and optic nerve head play an important role in the pathogenesis of ...
Khulan Batsuuri   +4 more
wiley   +1 more source

The effect of dietary pioglitazone supplementation on milk yield, insulin sensitivity and GH–IGF‐I axis in Holstein dairy cows during the transition period

open access: yesVeterinary Medicine and Science, Volume 9, Issue 1, Page 336-344, January 2023., 2023
The high‐yielding dairy cows suffer from insulin resistance during the periparturient period. Dietary supplementation of pioglitazone hydrochloride, an insulin‐resistance drug and synthetic agonist for PPRAγ, improved the insulin sensitivity index (RQICKI‐BHBA) in Holstein dairy cows during the transition period. Abstract Background High‐yielding dairy
Saeed Mirzaie   +4 more
wiley   +1 more source

The Autophagic Activator GHF-201 Can Alleviate Pathology in a Mouse Model and in Patient Fibroblasts of Type III Glycogenosis

open access: yesBiomolecules
Glycogen storage disease type III (GSDIII) is a hereditary glycogenosis caused by deficiency of the glycogen debranching enzyme (GDE), an enzyme, encoded by Agl, enabling glycogen degradation by catalyzing alpha-1,4-oligosaccharide side chain transfer ...
Kumudesh Mishra   +11 more
doaj   +1 more source

Gluconeogenesis and glycogenolysis required in metastatic breast cancer cells

open access: yesFrontiers in Oncology
IntroductionMetabolic adaptability, including glucose metabolism, enables cells to survive multiple stressful environments. Glycogen may serve as a critical storage depot to provide a source of glucose during times of metabolic demand during the ...
Emily Hicks   +12 more
doaj   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

open access: yesInternational Journal of Cancer, EarlyView.
What's New? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita   +12 more
wiley   +1 more source

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase b Complexes

open access: yesPolysaccharides
Glycogen is a natural polysaccharide used as an energy storage macromolecule. The role of glycogen metabolism in type 2 diabetes mellitus has been under investigation for several years, along with its implication in cancer and cardiovascular and ...
Pandora Karakousi   +3 more
doaj   +1 more source

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