Results 141 to 150 of about 182,661 (268)

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Activation of ATP Consumption Is Necessary to Stimulate Glycogenolysis in Skeletal Muscle. [PDF]

Int J Mol Sci
Martinov MV, Sudarkina SI, Ataullakhanov FI, Vitvitsky VM.   +3 more
europepmc   +1 more source

Hydrolysis of Glycogen

The Journal of Physiology, 1898
openaire   +3 more sources

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Iodine Staining of Glycogen Storage in <i>Caenorhabditis elegans</i>. [PDF]

Bio Protoc
Daghar H, Samarut É, Parker AJ.
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides). [PDF]

FASEB J
Tao J, Chen S, Liu N, Gong Y, Zhang S, He J, Huang X, Chen N, Li S.   +8 more
europepmc   +1 more source

Multi‐Vendor and Multi‐Site Characterization of 13C Coils for Clinical Studies

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Due to the inherently low signal‐to‐noise ratio (SNR) domain for 13C imaging, optimal coil performance is essential to maximize data quality. Quality control (QC) for 13C coils employed in magnetic resonance spectroscopy (MRS) is of paramount importance.
Emil S. Christensen, Andreas Clemmensen, Esben S. S. Hansen, Jonathan Birchall, Mary A. McLean, Christoffer Laustsen, Andreas Kjaer, Thomas L. Andersen   +7 more
wiley   +1 more source

Rethinking Vaginal Microbiome Resilience: A Conceptual Multi-Omic Framework. [PDF]

Microorganisms
Cagle-White B, Carpenter RE, Vincent A, Kominek E, Krouse A.   +4 more
europepmc   +1 more source

Design of an In Vivo‐Like Phantom for Quantitative Body CEST MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To design and validate a reproducible in vivo‐like fat‐containing CEST phantom that enables robust quantitative CEST MRI for body applications by providing physiologically realistic relaxation properties, relevant endogenous CEST contrasts (amide, guanidino, rNOE, and semi‐solid MT), and a controlled fat component.
Petr Menshchikov, Petr Bulanov, Neele Kempa, Mark E. Ladd, Andreas Korzowski, Philip S. Boyd   +5 more
wiley   +1 more source