Results 161 to 170 of about 182,661 (268)

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Central nervous system histopathological findings in classic infantile Pompe disease: a systematic review with clinical relevance. [PDF]

J Neurol
van den Dorpel JJA, Faraguna MC, Verdijk RM, van der Beek NAME, Pijnappel WWMP, van der Ploeg AT, van den Hout JMP.   +6 more
europepmc   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Genome Editing for Glycogen Storage Diseases. [PDF]

J Inherit Metab Dis
von Beck T, Wang R, Koeberl D.
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

AMPKγ2 Meets Myosin: A New Link Between Metabolism and Sarcomere Function. [PDF]

Circ Res
Gao S, Chen SN, Taylor MRG, Mestroni L.
europepmc   +1 more source

A Digital Atlas of Human Ultrastructure

Small, EarlyView.
An interactive resource with ultrastructural data of human organs. Analyse organs from sub‐millimeter up to the nanometer range of macromolecules in a similar way as Google‐earth: https://www.nanotomy.org/OA/HumanAtlas/. ABSTRACT Electron microscopy (EM) is the method to visualize the building blocks of life in organs and tissues at biomolecular ...
Anouk H. G. Wolters, Kim Kats, Jeroen Kuipers, Erik Bleuel, Ben N. G. Giepmans   +4 more
wiley   +1 more source

GAA engineered to improve cellular uptake enhances correction in a preclinical hematopoietic stem cell gene therapy model of Pompe disease. [PDF]

Mol Ther Adv
Wantuch S, Tuske S, Benedetti S, Mehta N, Brudvig JJ, Do H, Gotschall R, Feng J, Gaspar AB, Recchi C, Heal P, Johnson TB, Mavilio F, Sagoo P, Weimer JM, Gaspar HB.   +15 more
europepmc   +1 more source

Rotenone Induces Morphological Damage and Reduction in Catecholamine Levels in the Central Nervous System of the Ascidian Styela plicata

Environmental Toxicology, EarlyView.
ABSTRACT Ascidians are invertebrates that occupy a key phylogenetic position as a sister group of the vertebrates. The organization of their central nervous system (CNS), with cortex and medulla, indicates a plesiomorphic character of the gray and white matter of vertebrates, making this group of animals useful for studies of neurodegenerative events ...
Andressa de Abreu Mello, Carlos Augusto Borges de Andrade Gomes, Rafaela Rocha dos Santos, Cintia Monteiro de Barros, Silvana Allodi   +4 more
wiley   +1 more source

Dura mater‐preserving technique for fetal brain extraction after intrauterine death with prolonged retention

Journal of Forensic Sciences, EarlyView.
Abstract Examination of the fetal brain represents a crucial step in the diagnostic assessment of fetal death in utero, particularly in cases of unexplained intrauterine fetal death (IUFD). Prolonged intrauterine retention, advanced autolysis, and the intrinsic structural immaturity of the fetal brain frequently compromise tissue integrity, limiting ...
Ezio Fulcheri, Francesca Buffelli, Sharon Duzioni, Francesco Lupariello, Francesca Pesce, Valerio Gaetano Vellone, Alessandro Bonsignore   +6 more
wiley   +1 more source