Results 11 to 20 of about 425,174 (291)

Glycogenin is Dispensable for Glycogen Synthesis in Human Muscle, and Glycogenin Deficiency Causes Polyglucosan Storage [PDF]

, 2020
Glycogenin is considered to be an essential primer for glycogen biosynthesis. Nevertheless, patients with glycogenin-1 deficiency due to biallelic GYG1 (NM_004130.3) mutations can store glycogen in muscle.
Dellgren, Göran, Glamuzina, Emma, Hedberg-Oldfors, Carola, Hernandez-Lain, Aurelio, Kornblum, Cornelia, Oldfors, Anders, Roach, Peter, Sandstedt, Joakim, Tasca, Giorgio, Thomsen, Christer, Visuttijai, Kittichate   +10 more
core   +1 more source

Comprehensive Analysis of Differentially Expressed mRNA, Non-coding RNA, and Their Competitive Endogenous RNA Network of Pacific Oyster Crassostrea gigas With Different Glycogen Content Between Different Environments

Frontiers in Marine Science, 2021
Glycogen content is a quantitative trait, its phenotype differences are found between individual oysters due to genetic effects and environmental factors which were including food, water temperature, salinity, and so on.
Xue Wang, Weijun Wang, Zan Li, Guohua Sun, Tao Xu, Xiaohui Xu, Yanwei Feng, Qihao Luo, Bin Li, Bin Li, Jianmin Yang, Jianmin Yang   +11 more
doaj   +1 more source

Incorporation of phosphate into glycogen by glycogen synthase [PDF]

Archives of Biochemistry and Biophysics, 2016
The storage polymer glycogen normally contains small amounts of covalently attached phosphate as phosphomonoesters at C2, C3 and C6 atoms of glucose residues. In the absence of the laforin phosphatase, as in the rare childhood epilepsy Lafora disease, the phosphorylation level is elevated and is associated with abnormal glycogen structure that ...
Christopher J. Contreras, Dyann M. Segvich, Krishna Mahalingan, Vimbai M. Chikwana, Terence L. Kirley, Thomas D. Hurley, Anna A. DePaoli-Roach, Peter J. Roach   +7 more
openaire   +4 more sources

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

Nature Communications, 2020
Our current understanding of how sugar metabolism affects inflammatory pathways in macrophages is incomplete. Here, we show that glycogen metabolism is an important event that controls macrophage-mediated inflammatory responses.
Jingwei Ma, Keke Wei, Junwei Liu, K. Tang, Huafeng Zhang, Liyan Zhu, Jie Chen, Fei Li, P. Xu, Jie Chen, Jincheng Liu, Haiqing Fang, Liang V. Tang, Dianheng Wang, Liping Zeng, Weiwei Sun, Jing Xie, Yuying Liu, Bo Huang   +18 more
semanticscholar   +1 more source

Crosstalk between beta‐adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in liver of high‐fat diet‐fed male mice

Physiological Reports, 2021
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. While increased nutrient intake and sympathetic activity have been associated with the disease, the pathogenesis of NAFLD remains incompletely understood.
Sadia Ashraf, Nadia Ashraf, Gizem Yilmaz, Romain Harmancey   +3 more
doaj   +1 more source

Liver Glycogen Synthase in Rats with a Glycogen‐Storage Disorder [PDF]

European Journal of Biochemistry, 1980
1. A strain of rats with a genetically‐determined liver glycogen‐storage disorder (gsd/gsd) caused by a deficiency of liver phosphorylase kinase has a very high concentration of glycogen in the liver with a total glycogen synthase activity higher than in liver of fed normal animals, but only a small amount of the enzyme in the active form.
Colin Watts, Rex S. Malthus
openaire   +3 more sources

Action Patterns of Phosphorylase and Glycogen Synthetase on Glycogen [PDF]

European Journal of Biochemistry, 1970
The action patterns of liver and muscle glycogen synthetases and of muscle phosphorylase b on glycogen samples of different molecular weight and on β‐amylase limit dextrins were studied. For this purpose a method for measuring the number of newly added glucose residues that are at non‐reducing ends was developed.It was found that glucose transfer to ...
Parodi, Armando José A., Mordoh, Jose, Krisman, Clara R., Leloir, Luis Federico   +3 more
openaire   +4 more sources

Metabolic control analysis of hepatic glycogen synthesis in vivo

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Hepatic glycogen synthesis plays a critical role in maintaining normal glucose homeostasis; however, the rate-controlling step regulating this process is unknown.
Y. Nozaki, Max C. Petersen, Dongyan Zhang, D. Vatner, R. Perry, Abudukadier Abulizi, S. Haedersdal, Xian‐Man Zhang, G. Butrico, V. Samuel, G. Mason, G. Cline, K. Petersen, D. Rothman, G. Shulman   +14 more
semanticscholar   +1 more source

Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. [PDF]

, 2014
Glycogen and lipids are major storage forms of energy that are tightly regulated by hormones and metabolic signals. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen due to increased expression of the glycogenic ...
Bridges, Dave, Chang, Louise, Cheng, Alan, Downes, Michael, Evans, Ronald M, Fisher, Kaleigh, Liddle, Christopher, Lin, Jiandie D, Lu, Binbin, Meng, Zhuo-Xian, Saltiel, Alan R, Yang, Yemen, Yu, Ruth T   +12 more
core   +2 more sources

Magnetic resonance imaging of glycogen using its magnetic coupling with water

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Glycogen is the primary form of glucose storage in mammals and plays a vital role in cellular energy homeostasis. Mapping glycogen in vivo is useful in diagnosis and assessment of diseases where glucose metabolism is altered, such as ...
Yang Zhou, P. V. van Zijl, Xiang Xu, Jiadi Xu, Yuguo Li, Lin Chen, N. Yadav   +6 more
semanticscholar   +1 more source