Results 161 to 170 of about 36,696 (264)

Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease

The Journal of Physiology, EarlyView.
Abstract figure legend This review utilized animal models of complicated human pregnancies that result in reduced fetal nutrient or oxygen delivery, or combined nutrient and oxygen delivery, to elucidate their independent and/or synergistic contributions to the development of high‐risk cardiac phenotypes.
Melanie R. Bertossa, Jack R. T. Darby, Ashley S. Meakin, Mitchell C. Lock, Steven K. S. Cho, Christopher K. Macgowan, Mike. Seed, Michael D. Wiese, Janna L. Morrison   +8 more
wiley   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

Noninfectious endocarditis as a novel cardiac manifestation of glycogen storage disease type IV: a case report. [PDF]

Transl Pediatr
Kingdon T, Ganta S, Shayan K, Schuchardt EL, Gomez-Arostegui J, Vellore Govardhan S.   +5 more
europepmc   +1 more source

Glucose and fructose contributions to exogenous carbohydrate oxidation and performance at moderate altitude

The Journal of Physiology, EarlyView.
Abstract figure legend Co‐ingesting fructose with glucose increases exogenous carbohydrate oxidation at sea level, but its effect at altitude is unclear. This study compared glucose–fructose (GLU–FRU), glucose alone (GLU) and placebo during 120 min of running at 70% V̇O2max${{\dot{V}}_{{{{\mathrm{O}}}_2}{\mathrm{max}}}}$ at 2500 m in eight males.
Nicola C. Arjomandkhah, Andy J. King, Alex Griffiths, Roderick F. G. J. King, Douglas, J. Morrison, Thomas Preston, John P. O'Hara   +7 more
wiley   +1 more source

Improvement of Symptoms in a Patient With Glycogen Storage Disease Through Nutritional Guidance and Exercise Therapy. [PDF]

JCEM Case Rep
Morita T, Murakami T, Okamura E, Matsushiro M, Ito S, Yabe D.   +5 more
europepmc   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Maximal exercise at high altitude does not exacerbate inflammation in the human brain

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated arterial–internal jugular venous (IJV) exchange of cytokines in response to low‐intensity and maximal cycling exercise at sea level and following 6–8 days at 3800 m a.s.l. There was a shift towards net release of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1 (MCP‐1) and ...
Hannah G. Caldwell, Travis D. Gibbons, Connor A. Howe, Jack S. Talbot, Elliott J. Jenkins, L. Madden Brewster, Justin A. Monteleone, Jay M. J. R. Carr, Andrew R. Steele, Michael Stembridge, David B. MacLeod, Philip N. Ainslie   +11 more
wiley   +1 more source

Clinical and molecular characterization of hepatic glycogen storage disease in Saudi Arabia. [PDF]

PLoS One
Al-Hussaini A, AlMannai M, Alruwaithi M, Faqeih E, Alasmari A, Alfadhel M, Al Mutairi F, Saleh M, AlZaben A, Alobailan Y, Alharbi M, AlAfqi M, Alayed A, Peer-Zada AA, Alrusayni Y.   +14 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Liver-directed AAV gene therapy in mice corrects glycogen storage disease type IX γ2. [PDF]

Sci Adv
Gibson RA, Jeck WR, Koch RL, Jumani N, Choi SJ, Bali D, Young SP, Asokan A, Lim JA, Kishnani PS.   +9 more
europepmc   +1 more source