Results 91 to 100 of about 454,859 (358)

The role of zinc in renal pathological changes in diabetic status [PDF]

open access: yes, 2015
Diabetes mellitus (DM) was the 8th leading cause of death in 2011, resulting in 1.4 million deaths worldwide. One of the complications of DM is chronic kidney disease, which accounts for nearly 44% of all new cases of kidney failure in the US in 2011 ...
Fernando, Julie, Zhou, Shaobo
core   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves   +3 more
wiley   +1 more source

Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain [PDF]

open access: yes, 1983
A calcium and calmodulin-dependent protein kinase has been purified from rat brain. It was monitored during the purification by its ability to phosphorylate the synaptic vesicle-associated protein, synapsin I.
Bennett, Mark K.   +2 more
core  

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

open access: yes, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta   +12 more
core   +3 more sources

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

open access: yesCell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio   +6 more
wiley   +1 more source

Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

open access: yes, 2006
Glycogen availability can influence glucose transporter 4 (GLUT4) expression in skeletal muscle through unknown mechanisms. The multisubstrate enzyme AMP-activated protein kinase (AMPK) has also been shown to play an important role in the regulation of ...
Chan, Stanley   +7 more
core   +1 more source

The role of Computer Aided Process Engineering in physiology and clinical medicine [PDF]

open access: yes, 2009
This paper discusses the potential role for Computer Aided Process Engineering (CAPE) in developing engineering analysis and design approaches to biological systems across multiple levels—cell signalling networks, gene, protein and metabolic networks ...
Allen, R., Bogle, I.D.L., Sumner, T.
core   +1 more source

Glycogen synthase kinase-3 signaling in Alzheimer's disease.

open access: yesBiochimica et biophysica acta. Molecular cell research, 2020
E. Lauretti, Ozlem Dincer, D. Praticò
semanticscholar   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

open access: yesChemistryEurope, EarlyView.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés   +5 more
wiley   +1 more source

Elevated glycogen synthase kinase 3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential [PDF]

open access: yes, 2007
Significant advances have been made in understanding the underlying defects of and developing potential treatments for Fragile X Syndrome (FXS), the most common heritable mental retardation.
Bauchwitz, Dr. Robert P.
core  

Home - About - Disclaimer - Privacy