Results 131 to 140 of about 448,615 (401)
Chemistry &Biodiversity, Accepted Article.The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Analyzing conformational changes in single FRET-labeled A1 parts of archaeal A1AO-ATP synthase [PDF]
arXiv, 2018 ATP synthases utilize a proton motive force to synthesize ATP. In reverse, these membrane-embedded enzymes can also hydrolyze ATP to pump protons over the membrane. To prevent wasteful ATP hydrolysis, distinct control mechanisms exist for ATP synthases in bacteria, archaea, chloroplasts and mitochondria.
arxiv
Integrated functions among multiple starch synthases determine both amylopectin chain length and branch linkage location in Arabidopsis leaf starch [PDF]
, 2011 This study assessed the impact on starch metabolism in Arabidopsis leaves of simultaneously eliminating multiple soluble starch synthases (SS) from among SS1, SS2, and SS3.
D'Hulst, Christophe +7 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters +5 more
wiley +1 more source
Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022 Breast cancer (BC) is one of the most challenging cancers to treat. Nutraceuticals acting by attenuating Hedgehog, NF‐κB, and Wnt/β‐catenin pathways. Nutraceuticals have medical characteristics and may cure cancer Abstract Breast cancer (BC) is one of the most challenging cancers to treat, accounting for many cancer‐related deaths.
Khalid Saad Alharbi +11 more
wiley +1 more source
Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423 [PDF]
arXiv, 2018 Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase and induces apoptosis via increased reactive oxygen ...
arxiv
Simultaneous monitoring of the two coupled motors of a single FoF1-ATP synthase by three-color FRET using duty cycle-optimized triple-ALEX [PDF]
, 2009 FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. Briefly, proton translocation through the membrane-bound Fo part of ATP synthase drives a 10-step rotary motion of the ring of c ...
arxiv +1 more source
Alzheimer's disease pathology and the unfolded protein response : Prospective pathways and therapeutic targets [PDF]
, 2017 The authors would like to thank Alzheimer's Research UK (Grant refs: ARUK-PPG2014A-21 and ARUK-NSG2015-1 to BP and DK) who have provided support for relevant projects leading to this review.Peer ...
Koss, David J, Platt, Bettina
core +1 more source
European Journal of Organic Chemistry, EarlyView.Syntheses of quinoline and quinoxaline derivatives fused with phosphacycles were developed from commercially available quinolin‐6‐amine and quinoxalin‐6‐amine. Abstract Despite their potential in areas such as medicinal chemistry and organic materials, scaffolds in which quinoline and quinoxaline are fused to phosphacycles such as 1,3‐oxaphosphole, 1,3‐
Mohamed Ali Dridi +9 more
wiley +1 more source
Oral Diseases, Volume 29, Issue 1, Page 116-127, January 2023., 2023 Abstract Objective This study was designed to identify changes in the expression of proteins occurring during the progression of oral squamous cell carcinoma (OSCC) and to validate their impact on patient prognosis. Materials and Methods The human OSCC cell line UPCI‐SCC‐040 was treated in vitro with TGF‐β1, and transcriptome analysis of differentially
Boris Schminke +8 more
wiley +1 more source