Results 161 to 170 of about 448,615 (401)

Effects of starvation on the carbohydrate metabolism in Harmonia axyridis (Pallas)

Biology Open, 2017
Trehalose plays an important role in energy storage, metabolism, and protection from extreme environmental conditions in insects. Trehalose is the main blood sugar in insects, and it can be rapidly used as an energy source in times of need.
Zuo-Kun Shi, Su Wang, Shi-Gui Wang, Lu Zhang, Yan-Xia Xu, Xiao-Jun Guo, Fan Zhang, Bin Tang   +7 more
doaj   +1 more source

Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens

Journal of Inflammation, 2012
Glycogen synthase kinase 3β (GSK3β) plays a fundamental role during the inflammatory response induced by bacteria. Depending on the pathogen and its virulence factors, the type of cell and probably the context in which the interaction between host cells ...
Ricarda Cortés-Vieyra, A. Bravo-Patiño, J. J. Valdez-Alarcón, Marcos Cajero Juárez, Brett Finlay, V. M. Baizabal-Aguirre   +5 more
semanticscholar   +1 more source

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

iMeta, EarlyView.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao, Huiyue Zhong, Yue He, Xiaojiao Li, Li Zhu, Zhanbo Xiong, Xiaoyin Zhang, Nan Zheng, Diego P. Morgavi, Jiaqi Wang   +9 more
wiley   +1 more source

Vitamin C deficiency induces hypoglycemia and cognitive disorder through S-nitrosylation-mediated activation of glycogen synthase kinase 3β

Redox Biology, 2022
Vitamin C (VC, l-ascorbic acid) is an essential nutrient that plays a key role in metabolism and functions as a potent antioxidant in regulating the S-nitrosylation and denitrosylation of target proteins. The precise function of VC deprivation in glucose
Yingying Shu, Chaochun Zou, Yuqing Cai, Qiangqiang He, Xiaowei Wu, Haibin Zhu, Meiyu Qv, Yunqi Chao, Chengyun Xu, Lanfang Tang, Ximei Wu   +10 more
doaj  

Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors

Molecules, 2018
Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism.
Daniela Hulcová, Kateřina Breiterová, Tomáš Siatka, Kamila Klímová, Lara Davani, Marcela Šafratová, Anna Hošťálková, Angela De Simone, Vincenza Andrisano, Lucie Cahlíková   +9 more
doaj   +1 more source

Synthetic Biology in Leishmaniasis: Design,simulation and validation of constructed Genetic circuit [PDF]

arXiv, 2013
Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies, and interactions for the design of robust synthetic systems. To the best of our knowledge,there are no literature
arxiv  

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

iMeta, EarlyView.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen, Wenxin Qu, Mengdi Song, Tianyu Zhang, Chang Liu, Xiaofeng Shi, Xinxin Xu, Jingjing Jiang, Liguo Ding, Fangyu Mo, Zheying Mao, Mingzhu Huang, Ziye Xu, Jiaye Chen, Enhui Shen, Jian Ruan, Jiong Liu, Michael P. Timko, Yu Chen, Longjiang Fan, Shufa Zheng, Yongcheng Wang   +21 more
wiley   +1 more source

Research advances of glycogen synthetic kinase-3β in diabetic nephropathy

Linchuang shenzangbing zazhi, 2021
The pathogenesis of diabetic kidney disease（DKD）is rather complicated.And glycogen synthase-3 plays important roles in many signaling pathways in body.For chronic kidney injury caused by diabetes, it is involved in the damage process of glomerular ...
He Zhi-xiu, Ma Chan-juan
doaj  

Regulatory conformational changes of the epsilon subunit in single FRET-labeled FoF1-ATP synthase [PDF]

arXiv, 2014
Subunit epsilon is an intrinsic regulator of the bacterial FoF1-ATP synthase, the ubiquitous membrane-embedded enzyme that utilizes a proton motive force in most organisms to synthesize adenosine triphosphate (ATP). The C-terminal domain of epsilon can extend into the central cavity formed by the alpha and beta subunits, as revealed by the recent X-ray
arxiv  

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, EarlyView.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source