The multifaceted roles of ketones in physiology
Abstract The production of ketones, referred to as ketogenesis, plays an essential role in maintaining energy homeostasis during prolonged fasting/starvation, which primarily stems from its ability to serve as a fuel source to support neuronal ATP production, thereby limiting muscle wasting. Over the years, the field has come to appreciate that ketones
Seyed Amirhossein Tabatabaei Dakhili+3 more
wiley +1 more source
Radiosynthesis and evaluation of a novel <sup>18</sup>F-labeled tracer for PET imaging of glycogen synthase kinase 3. [PDF]
Xiao Z+15 more
europepmc +1 more source
Elevated cortisol concentration in preterm sheep fetuses impacts heart development
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi+9 more
wiley +1 more source
Natural compounds from herbs and nutraceuticals as glycogen synthase kinase-3β inhibitors in Alzheimer's disease treatment. [PDF]
Zhao Z, Yuan Y, Li S, Wang X, Yang X.
europepmc +1 more source
In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene+4 more
wiley +1 more source
Lithium alleviates paralysis in experimental autoimmune neuritis in Lewis rats by modulating glycogen synthase kinase-3β activity. [PDF]
Ahn M.
europepmc +1 more source
Downregulation of microRNA‐494 drives mitochondrial biogenesis and function in trained muscle
Abstract MicroRNAs (miRNAs) are key regulators of cellular processes, including mitochondrial function and energy metabolism. This study explores the regulation of miR‐494 in skeletal muscle and circulation, investigating its response to exercise training and an acute exercise bout, its association with metabolic disorders, and the effects of ...
Natália Pálešová+10 more
wiley +1 more source
Glycogen synthase kinase 3 activity enhances liver inflammation in MASH. [PDF]
Khoury M+19 more
europepmc +1 more source