Results 291 to 300 of about 448,615 (401)

Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: Glycogen overproduction induces apoptosis in male germ cells

Journal of Cellular Biochemistry, 2013
F. Villarroel-Espíndola, Rodrigo Maldonado, Hector Mancilla, Karen vander Stelt, A. I. Acuña, A. Covarrubias, Camila López, C. Angulo, M. Castro, Juan Carlos Slebe, Jordi Duran, M. Garcı́a-Rocha, J. Guinovart, I. Concha   +13 more
semanticscholar   +1 more source

Lamellarin D Acts as an Inhibitor of Type I Collagen Production

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno, Noriho Sakamoto, Hideki Hayashi, Tsutomu Fukuda, Yoshiko Akiyama, Chiaki Iketani, Ritsuko Murakami, Takatomo Tokito, Takuto Miyamura, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Shinnosuke Takemoto, Takahiro Takazono, Tomoya Nishino, Yuji Ishimatsu, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae   +19 more
wiley   +1 more source

Lithium alleviates paralysis in experimental autoimmune neuritis in Lewis rats by modulating glycogen synthase kinase-3β activity. [PDF]

J Vet Sci
Ahn M.
europepmc   +1 more source

In VivoInsulin Signaling in the Myocardium of Streptozotocin-Diabetic Rats: Opposite Effects of Diabetes on Insulin Stimulation of Glycogen Synthase and c-Fos¹ [PDF]

, 1999
Ping H. Wang, Abdulraof Almahfouz, Francesco Giorgino, Karen C. McCowen, Robert J. Smith   +4 more
openalex   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, Volume 12, Issue 17, May 8, 2025.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Expanding therapeutic options for Pompe disease: a new small molecule inhibitor of glycogen synthase 1 (GYS1) shows preclinical promise in Pompe disease. [PDF]

Ann Transl Med
Koch RL, Cocanougher BT, Lim JA, Raben N, Kishnani PS.   +4 more
europepmc   +1 more source

Inhibitor-1 Is Not Required for the Activation of Glycogen Synthase by Insulin in Skeletal Muscle [PDF]

, 1999
Angus G. Scrimgeour, Patrick B. Allen, Allen A. Fienberg, Paul Greengard, John C. Lawrence   +4 more
openalex   +1 more source

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS‐AD‐linked degenerative phenotypes in the Dp16 mouse model of Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION Down syndrome (DS) markedly raises the risk of Alzheimer's disease (DS‐AD). Our findings identified widespread dysregulation of the endolysosomal network (ELN) in DS and DS‐AD brains, driven by increased APP gene dose, hyperactivation of RAB5, and elevated levels of guanine nucleotide exchange factors (GEFs) for RABs 7 and 11 ...
Xu‐Qiao Chen, Xinxin Zuo, Ann Becker, Michael Mante, Jazmin B. Florio, Satish G. Jadhav, Ricardo Albay, Aaron Johnstone, Dmitry Karachentsev, Robert Rissman, Hien Zhao, Steven F. Dowdy, William C. Mobley   +12 more
wiley   +1 more source

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. [PDF]

, 1996
David P. Cook, Michael Fry, K. Hughes, Rushika Sumathipala, James R. Woodgett, Trevor Dale   +5 more
openalex   +1 more source

Targeting Triple‐Negative Breast Cancer: Resistance Mechanisms and Therapeutic Advancements

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Triple‐negative breast cancer (TNBC) is one of the most heterogeneous and menacing forms of breast cancer, with no sustainable cure available in the current treatment landscape. Its lack of targets makes it highly unresponsive to various treatment modalities, which is why chemotherapy continues to be the primary form of treatment ...
Rachana Raman, Shristi Debata, Thirupugal Govindarajan, Praveen Kumar   +3 more
wiley   +1 more source