Results 311 to 320 of about 454,859 (358)

Indices of the activation state of glycogen synthase

Analytical Biochemistry, 1980
Abstract Glucose 6-phosphate dependency relationships, Hill Plots, and apparent A0.5 glucose 6-phosphate values have been computed for mixtures of discrete forms of glycogen synthase. From these calculated values and by inspection of the ensuing graphs an asseessment can be made of the usefulness and limitations of I D relationships and A0.5 ...
Scott M. Van Patten, Donal A. Walsh
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Inhibition of Glycogen Synthase Kinase-3

2008
There are two homologous forms of glycogen synthase kinase (GSK)-3, GSK-3alpha and GSK-3beta, which play overlapping roles in the regulation of Wnt, Hedgehog, and insulin pathways, as well as the activation of nuclear factor (NF)-kappaB-mediated gene transcription.
Daniel D. Billadeau, Andrei V. Ougolkov
openaire   +3 more sources

Action pattern of muscle glycogen synthase

Molecular and Cellular Biochemistry, 1975
The action pattern of muscle glycogen synthaseI form was investigated by means of a study of the distribution of radioactive glucosyl units in the glycogen synthesized under variable concentrations of the substrates UDP-glucose and glycogen. A multiple chain mechanism was found to be operative.
Eduardo Salsas, Joseph Larner
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An improved rapid assay of glycogen synthase

Analytical Biochemistry, 1979
Abstract As an alternative to rapid filtration washing the glycogen free of any unreacted UDP-[14C]-glucose by ascending chromatography (ethanol:water, 2:1) can be used. This technique also makes the filter paper assay of glycogen synthase much faster: The samples are ready for liquid scintillation counting in 30 min.
Emma Villa-Moruzzi, Teresa Locci-Cubeddu, Ettore Bergamini   +2 more
openaire   +3 more sources

Characterization of human endometrial glycogen synthase

Fertility and Sterility, 1994
To characterize and compare human endometrial glycogen synthase complementary DNA (cDNA) to the published rat liver and human skeletal muscle glycogen synthase transcripts and then to determine whether P-induced glycogen accumulation in endometrium is accompanied by a rise in glycogen synthase transcripts.We performed bidirectional sequencing of ...
Gayla S. Harris, Sander S. Shapiro, Linda A. Schuler   +2 more
openaire   +3 more sources

Trehalose synthase converts glycogen to trehalose

The FEBS Journal, 2008
Trehalose (α,α‐1,1‐glucosyl‐glucose) is essential for the growth of mycobacteria, and these organisms have three different pathways that can produce trehalose. One pathway involves the enzyme described in the present study, trehalose synthase (TreS), which interconverts trehalose and maltose.
Alan D. Elbein, Naoki Asano, J. D. Carroll, Irena Pastuszak, Y. T. Pan, Vineetha Koroth Edavana   +5 more
openaire   +3 more sources

Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α

Journal of Medicinal Chemistry, 2012
The glycogen synthase kinase-3 (GSK-3) has been linked to the pathogenesis of colorectal cancer, diabetes, cardiovascular disease, acute myeloid leukemia (AML), and Alzheimer's disease (AD). The debate on the respective contributions of GSK-3α and GSK-3β to AD pathology and AML is ongoing. Thus, the identification of potent GSK-3α-selective inhibitors,
Lo Monte F., Kramer T., Gu J., Anumala U. R., MARINELLI, LUCIANA, LA PIETRA, VALERIA, NOVELLINO, ETTORE, Franco B., Demedts D., Van Leuven F., Fuertes A, Dominguez JM, Plotkin B, Eldar Finkelman H, Schmidt B.   +14 more
openaire   +4 more sources

Multisite phosphorylation of glycogen synthase

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1984
Glycogen synthase kinase-3 was isolated from rabbit skeletal muscle by an improved procedure. The purification was estimated to be 67000-fold and 0.2 mg of enzyme was isolated from 5000 g muscle, corresponding to an overall yield of 7%. The preparation was homogeneous by ultracentrifugal and electrophoretic criteria. The enzyme had a relative molecular
Woodgett, James R., Cohen, Philip
openaire   +4 more sources

glycogen synthase

Catalysis from A to Z, 2020
S. Reisse
semanticscholar   +1 more source

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Nature, 1995
D. Cross, D. Alessi, P. Cohen, Mirjana Andjelkovich, B. Hemmings   +4 more
semanticscholar   +1 more source