Results 21 to 30 of about 30,904 (216)

Stimulation of Natural Killer T Cells by Glycolipids

Molecules, 2013
Natural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to ...
Brian L. Anderson, Luc Teyton, Albert Bendelac, Paul B. Savage   +3 more
doaj   +1 more source

Glycolipids: Linchpins in the Organization and Function of Membrane Microdomains

Frontiers in Cell and Developmental Biology, 2020
Membrane microdomains, also called lipid rafts, are areas on membrane enriched in glycolipids, sphingolipids, and cholesterol. Although membrane microdomains are thought to play key roles in many cellular functions, their structures, properties, and ...
Kei Hanafusa, Tomomi Hotta, Kazuhisa Iwabuchi, Kazuhisa Iwabuchi   +3 more
doaj   +1 more source

Glycolipid transfer proteins [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007
Glycolipid transfer proteins (GLTPs) are small (24 kDa), soluble, ubiquitous proteins characterized by their ability to accelerate the intermembrane transfer of glycolipids in vitro. GLTP specificity encompasses both sphingoid- and glycerol-based glycolipids, but with a strict requirement that the initial sugar residue be beta-linked to the hydrophobic
Rhoderick E, Brown, Peter, Mattjus
openaire   +2 more sources

Glycosylation of Glycolipids in Cancer: Basis for Development of Novel Therapeutic Approaches

Frontiers in Oncology, 2013
Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Jose Luis Daniotti, Aldo Alejandro Vilcaes, Vanina eTorres Demichelis, Fernando Miguel Ruggiero, Macarena eRodriguez-Walker   +4 more
doaj   +1 more source

Comment on: “GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity”

Advanced Science, EarlyView.
ABSTRACT The recent study by Wang et al. introduces GLM7, a novel composite index integrating routine health indicators to enhance the diagnosis and prediction of multimorbidity. The study provides compelling evidence for the utility of cost‐effective biomarkers in large‐scale health screening.
Yiquan Wang, Tin‐Yeh Huang
wiley   +2 more sources

Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy

Nature Communications, 2021
Glycolipids are glycoconjugates with important biological functions, but techniques for their analysis are deficient. Here, the authors report the use of cryogenic gas-phase infrared spectroscopy to investigate isomerism in a set of immunologically ...
Carla Kirschbaum, Kim Greis, Eike Mucha, Lisa Kain, Shenglou Deng, Andreas Zappe, Sandy Gewinner, Wieland Schöllkopf, Gert von Helden, Gerard Meijer, Paul B. Savage, Mateusz Marianski, Luc Teyton, Kevin Pagel   +13 more
doaj   +1 more source

Glycolipids and their developmental patterns in chick thigh and leg muscles.

Journal of Lipid Research, 1982
Five major gangliosides and two major neutral glycolipids were isolated from chick thigh and leg muscles using Unisil column chromatography and preparative thin-layer chromatography.
M Saito, A Rosenberg
doaj   +1 more source

Water-soluble trehalose glycolipids show superior Mincle binding and signaling but impaired phagocytosis and IL-1β production

Frontiers in Molecular Biosciences, 2022
The tremendous potential of trehalose glycolipids as vaccine adjuvants has incentivized the study of how the structures of these ligands relate to their Mincle-mediated agonist activities.
M. A. Thathsaranie P. Manthrirathna, Emma M. Dangerfield, Emma M. Dangerfield, Shigenari Ishizuka, Shigenari Ishizuka, Aodhamair Woods, Brenda S. Luong, Brenda S. Luong, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Mattie S. M. Timmer, Mattie S. M. Timmer, Bridget L. Stocker, Bridget L. Stocker   +15 more
doaj   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

Transcription of genes involved in sulfolipid and polyacyltrehalose biosynthesis of Mycobacterium tuberculosis in experimental latent tuberculosis infection. [PDF]

PLoS ONE, 2013
The Influence of trehalose-based glycolipids in the virulence of Mycobacterium tuberculosis (Mtb) is recognised; however, the actual role of these cell-wall glycolipids in latent infection is unknown.
Jimmy E Rodríguez, Ana S Ramírez, Laura P Salas, Cecilia Helguera-Repetto, Jorge Gonzalez-y-Merchand, Carlos Y Soto, Rogelio Hernández-Pando   +6 more
doaj   +1 more source