Results 91 to 100 of about 260,676 (239)

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages

Nature Metabolism, 2023
M. Schilperoort, D. Ngai, M. Katerelos, D. Power, I. Tabas   +4 more
semanticscholar   +1 more source

TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

Journal of Hematology & Oncology, 2016
Background Cancer cells show increased glycolysis and take advantage of this metabolic pathway to generate ATP. The TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits aerobic glycolysis and protects tumor cells from intracellular reactive ...
Sixuan Qian, Jianyong Li, Ming Hong, Yu Zhu, Huihui Zhao, Yue Xie, Jiayu Huang, Yun Lian, Yanru Li, Shuai Wang, Jianping Mao, Yaoyu Chen   +11 more
doaj   +1 more source

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Nature Communications, 2015
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty ...
N. Patsoukis, Kankana Bardhan, Pranam Chatterjee, Duygu Sari, Bianling Liu, L. N. Bell, Edward D. Karoly, G. Freeman, V. Petkova, P. Seth, Lequn Li, V. Boussiotis   +11 more
semanticscholar   +1 more source

p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP

Cell Reports, 2023
Summary: Aerobic glycolysis is critical for cancer progression and can be exploited in cancer therapy. Here, we report that the human carboxymethylenebutenolidase homolog (carboxymethylenebutenolidase-like [CMBL]) acts as a tumor suppressor by ...
Yingdan Huang, Chen Xiong, Chunmeng Wang, Jun Deng, Zhixiang Zuo, Huijing Wu, Jianping Xiong, Xiaohua Wu, Hua Lu, Qian Hao, Xiang Zhou   +10 more
doaj  

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

Science, 2017
Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by ...
T. Park, J. Reznick, Bethany L. Peterson, Gregory Blass, Damir Omerbašić, N. Bennett, P. Henning J. L. Kuich, Christin Zasada, Brigitte M. Browe, Wiebke Hamann, Daniel T. Applegate, M. Radke, Tetiana Kosten, H. Lutermann, Victoria Gavaghan, Ole Eigenbrod, V. Bégay, Vince G Amoroso, V. Govind, R. Minshall, E. Smith, J. Larson, M. Gotthardt, S. Kempa, G. Lewin, G. Lewin   +25 more
semanticscholar   +1 more source

Biomolecular System Energetics [PDF]

arXiv, 2018
Efficient energy transduction is one driver of evolution; and thus understanding biomolecular energy transduction is crucial to understanding living organisms. As an energy-orientated modelling methodology, bond graphs provide a useful approach to describing and modelling the efficiency of living systems.
arxiv  

Selective advantage of aerobic glycolysis over oxidative phosphorylation [PDF]

arXiv
The utilization of glycolysis in aerobic conditions have been a subject of debate for more than a century. A hypothesis supported by previous data is that glycolysis has a higher rate of ATP production per protein mass and per occupied volume than oxidative phosphorylation (OxPhos).
arxiv  

Finding regulatory sites from statistical analysis of nucleotide frequencies in the upstream region of eukaryotic genes [PDF]

arXiv, 2002
We discuss two new approaches to extract relevant biological information on the Transcription Factors (and in particular to identify their binding sequences) from the statistical distribution of oligonucleotides in the upstream region of the genes.
arxiv  

Model-order reduction of biochemical reaction networks [PDF]

arXiv, 2012
In this paper we propose a model-order reduction method for chemical reaction networks governed by general enzyme kinetics, including the mass-action and Michaelis-Menten kinetics. The model-order reduction method is based on the Kron reduction of the weighted Laplacian matrix which describes the graph structure of complexes in the chemical reaction ...
arxiv  

Automated adaptive inference of coarse-grained dynamical models in systems biology [PDF]

arXiv, 2014
Cellular regulatory dynamics is driven by large and intricate networks of interactions at the molecular scale, whose sheer size obfuscates understanding. In light of limited experimental data, many parameters of such dynamics are unknown, and thus models built on the detailed, mechanistic viewpoint overfit and are not predictive.
arxiv