Results 91 to 100 of about 410,867 (397)

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

Molecular Cancer, 2019
Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target.
Yun Wang, Jia-huan Lu, Qi-Nian Wu, Ying Jin, Deshen Wang, Yanxing Chen, Jia Liu, Xiao-Jing Luo, Qi Meng, Heng-Ying Pu, Yingnan Wang, Pei-shan Hu, Ze-xian Liu, Z. Zeng, Qi Zhao, R. Deng, Xiao-Feng Zhu, Huai-qiang Ju, R. Xu   +18 more
semanticscholar   +1 more source

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Science, 2020
A metabolic circuit in T cell immunity Naïve T cells are metabolically reprogrammed when they differentiate into T effector (Teff) cells, transitioning from a reliance on mitochondrial oxidative phosphorylation to aerobic glycolysis. Xu et al. found that
Ke Xu, N. Yin, Min Peng, Efstathios G. Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J. Capistrano, Chun Chou, Andrew G Levine, A. Rudensky, Ming O. Li   +13 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

A new strategy for osteoarthritis therapy: Inhibition of glycolysis

Frontiers in Pharmacology, 2022
Osteoarthritis (OA) is a common degenerative disease of the joints. It is primarily caused by age, obesity, mechanical damage, genetics, and other factors, leading to cartilage degradation, synovial inflammation, and subchondral sclerosis with osteophyte
Chunmei Tan, Lanqing Li, Juanjuan Han, Kang Xu, Xianqiong Liu   +4 more
doaj   +1 more source

Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. [PDF]

, 2015
ATP is essential for cellular function and is usually produced through oxidative phosphorylation. However, mitochondrial dysfunction is now being recognized as an important contributing factor in the development cardiovascular diseases, such as pulmonary
Black, Stephen M, Desai, Ankit A, Fineman, Jeffrey R, Khalpey, Zain, Louise Meadows, Mary, Rafikov, Ruslan, Rafikova, Olga, Sun, Xutong, Yuan, Jason X-J   +8 more
core   +1 more source

Inhibition of aerobic glycolysis alleviates sepsis-induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK-regulated autophagy

International Journal of Molecular Medicine, 2021
Metabolism reprogramming influences the severity of organ dysfunction, progression to fibrosis, and development of disease in acute kidney injury (AKI).
Chuyi Tan, Jia Gu, Tao Li, Huan Chen, Ke Liu, Mei-dong Liu, Huali Zhang, Xianzhong Xiao   +7 more
semanticscholar   +1 more source

Aerobic Glycolysis in Osteoblasts [PDF]

Current Osteoporosis Reports, 2014
Osteoblasts, the chief bone-making cells in the body, are a focus of osteoporosis research. Although teriparatide, a synthetic fragment of the human parathyroid hormone (PTH), has been an effective bone anabolic drug, there remains a clinical need for additional therapeutics that safely stimulates osteoblast number and function.
Fanxin Long, Emel Esen
openaire   +3 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. [PDF]

, 2017
Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
Barcellos-Hoff, Mary Helen, Bayin, N Sumru, Chesler, Mitch, Chiriboga, Luis, Dolgalev, Igor, Doyle, Werner, Frenster, Joshua D, Galifianakis, Nataliya, Golfinos, John G, Heguy, Adriana, Illa-Bochaca, Irineu, Khahera, Anadjeet, Modrek, Aram S, Ortenzi, Valerio, Placantonakis, Dimitris G, Sen, Rajeev, Serrano, Jonathan, Si, Sheng, Snuderl, Matija, Tsirigos, Aristotelis, Zagzag, David   +20 more
core   +1 more source

Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]

, 2016
Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K., Mercer, John R., Salt, Ian P.   +2 more
core   +3 more sources