Results 101 to 110 of about 291,093 (299)

Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Cell Reports, 2018
Aerobic glycolysis accounts for ∼80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear.
Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, Claudio Punzo   +6 more
doaj   +1 more source

Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer

, 2018
Chen Xue,1,2,* Yuting He,1,2,* Qiuyue Hu,1,2 Yan Yu,1,2 Xiaolong Chen,1,2 Jianan Chen,1,2 Fang Ren,2 Juan Li,1,2 Zhigang Ren,1,2 Guangying Cui,1,2 Ranran Sun1–3 1Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University ...
Ren F, Li J, He Y, Xue C, Chen J, Ren Z, Sun R, Cui G, Chen X, Hu Q, Yu Y   +10 more
core  

Glycolysis/gluconeogenesis, trehalose and sucrose biosynthesis.

, 2012
A) Glycolysis/gluconeogenesis, trehalose and sucrose biosynthetic pathways. B) Transcript and metabolite profiles of glycolysis/gluconeogenesis. C) Transcript and metabolite profiles of sucrose biosynthetic pathways.
Raymond M. Wheeler (140980), Charles L. Guy (140983), Wei Zhao (14321), Lanfang H. Levine (140985), Fatma Kaplan (140972), Jeffrey T. Richards (140976)   +5 more
core   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Enhancing Student Comprehension of Glucose Metabolism Visualization Through Virtual Simulation Platform: An Educational Approach

Pharmacology Research & Perspectives
With the rapid progression of biotechnology, the significance translational research on glycolysis in molecular pharmacology has become increasingly evident.
Luna Ge, Tingting Feng, Shuo Cao, Hang Yin, Yuang Zhang, Jihong Pan, Wei Chen, Kai Cheng, Lin Wang   +8 more
doaj   +1 more source

Glycolysis Related Transcripts.

, 2012
The relative expression using 2-72 hr data is graphed for the annotated enzymes involved in glycolysis.
Shinichiro Enomoto (177957), Cheryl A. Lancto (177959), Mary J. Mauzy (177953), Mark S. Rutherford (177965), Mitchell S. Abrahamsen (177962)   +4 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Isoscopoletin inhibits hepatocellular carcinoma cell proliferation via regulating glycolysis-related proteins.

PLoS ONE
ObjectiveIsoscopoletin is one of the primary metabolites of natural product scoparone, which was reported to against tumor proliferation. The aim of this study was to explore the mechanism of isoscopoletin against hepatocellular carcinoma (HCC ...
Chenyao Ruan, Chen Wang, Chen Wang, Jiawen Gu, Zhihui Zhu   +4 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source