Results 131 to 140 of about 291,093 (299)

Studies in glycolysis [PDF]

Biochemical Journal, 1937
L P, Kendal, L H, Stickland
openaire   +4 more sources

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Integrated single-cell and clinical transcriptomic analysis identifies blunted glycolytic activation as a hallmark of maladaptive repair in renal ischemia–reperfusion

Renal Failure
Acute kidney injury (AKI) is a common and increases risk of chronic kidney disease (CKD). While mitochondrial dysfunction drives maladaptive repair, the role of glycolysis in renal recovery remains unclear.Here, we integrated single-cell transcriptomic ...
Alexandre Torck, Frédéric Sangla, Hervé Quintard, Maarten Naesens, David Legouis   +4 more
doaj   +1 more source

A STUDY OF GLYCOLYSIS [PDF]

Journal of Clinical Investigation, 1931
openaire   +2 more sources

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Vitamin D attenuates the progression of pulmonary fibrosis via inhibiting thymidine kinase 1/PFKFB3-driven glycolysis

Journal of Translational Medicine
Background Pulmonary fibrosis is characterized by the excessive deposition of extracellular matrix produced from myofibroblasts in the lungs. Enhanced glycolysis has been linked to fibroblast-myofibroblast transition (FMT) during pulmonary fibrogenesis ...
Huanyu Yang, Li Zhang, Mengjia Han, Keye Zhu, Xianghan Guo, Wenkang Yang, Qi Xu   +6 more
doaj   +1 more source

On Glycolysis in Blood [PDF]

Biochemical Journal, 1912
openaire   +2 more sources

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Single-cell and spatial transcriptomics reveal a high glycolysis B cell and tumor-associated macrophages cluster correlated with poor prognosis and exhausted immune microenvironment in diffuse large B-cell lymphoma

Biomarker Research
Background Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy characterized by varied responses to treatment and prognoses. Understanding the metabolic characteristics driving DLBCL progression is crucial for developing personalized ...
Liyuan Dai, Guangyu Fan, Tongji Xie, Lin Li, Le Tang, Haizhu Chen, Yuankai Shi, Xiaohong Han   +7 more
doaj   +1 more source