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Amplification and Preparation of Cellular O-Glycomes for Functional Glycomics
Analytical Chemistry, 2020Mucin-type O-glycans play key roles in many cellular processes, and they are often altered in human diseases. A major challenge in studying the role of O-glycans through functional O-glycomics is the absence of a complete repertoire of the glycans that comprise the human O-glycome. Here we describe a cellular O-glycome preparation strategy, Preparative
Zhonghua Li +11 more
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Emerging glycomics technologies
Nature Chemical Biology, 2007The nascent field of glycomics is currently undergoing rapid development, largely as a result of advances in technologies for analyzing glycan structure, unraveling glycan-protein interactions and establishing the functional significance of glycans. A meeting was held in November 2006 to explore the challenges and opportunities ahead for this emerging '
Turnbull, Jeremy E., Field, Robert A.
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2009
The ability to quantitatively determine changes is an essential component of comparative glycomics. Multiple strategies are available by which this can be accomplished. These include label-free approaches and strategies where an isotopic label is incorporated into the glycans prior to analysis.
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The ability to quantitatively determine changes is an essential component of comparative glycomics. Multiple strategies are available by which this can be accomplished. These include label-free approaches and strategies where an isotopic label is incorporated into the glycans prior to analysis.
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Separation technologies for glycomics
Journal of Chromatography B, 2002Progress in genome projects has provided us with fundamentals on genetic information; however, the functions of a large number of genes remain to be elucidated. To understand the in vivo functions of eukaryotic genes, it is essential to grasp the features of their post-translational modifications. Among them, protein glycosylation is a central issue to
Jun, Hirabayashi, Ken-ichi, Kasai
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Carbohydrate Arrays as Tools for Glycomics
Angewandte Chemie International Edition, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Love, K., Seeberger, P.
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New Technologies for Glycomic Analysis: Toward a Systematic Understanding of the Glycome
Annual Review of Analytical Chemistry, 2011Carbohydrates are the most difficult class of biological molecules to study by high-throughput methods owing to the chemical similarities between the constituent monosaccharide building blocks, template-less biosynthesis, and the lack of clearly identifiable consensus sequences for the glycan modification of cohorts of glycoproteins.
John F, Rakus, Lara K, Mahal
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Applications of chromatography in glycomics
Chinese Journal of ChromatographyGlycomics, an emerging "omics" technology that was developed after genomics and proteomics, is a discipline that studies the composition, structure, and functions of glycomes in cells, tissues, and organisms. Glycomics plays key roles in understanding the laws of major life activities, disease prevention and treatment, and drug quality control and ...
Yi, Zheng +4 more
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Oligosaccharide microarrays for glycomics
Trends in Biotechnology, 2003Glycomics is an emerging field that was proposed at the end of the 20th century as a new concept to follow genomics and proteomics. Studies on glycans are indispensable to define complex life systems and cell communities because all living organisms consist of diverse cells, which are covered with an abundance of heterogeneous carbohydrates.
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2004
The folk cures of early society have become the Complementary and Alternative Medicine of today. Basic science has unlocked many secrets of early herbal compounds and therapies. Computer science has aided in the opening of a new frontier called Glycobiology, the study of saccharides (sugars).
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The folk cures of early society have become the Complementary and Alternative Medicine of today. Basic science has unlocked many secrets of early herbal compounds and therapies. Computer science has aided in the opening of a new frontier called Glycobiology, the study of saccharides (sugars).
openaire +2 more sources