Results 191 to 200 of about 15,452 (231)
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Current Opinion in Chemical Biology, 2007
The study of protein-carbohydrate interactions is one central theme of glycomics research. The challenges encountered when investigating these interactions have resulted in an approach that studies saccharides through the enzymes that process them. Proteins and their function are often probed by manipulating the genes that encode them.
Timmer, M., Stocker, B., Seeberger, P.
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The study of protein-carbohydrate interactions is one central theme of glycomics research. The challenges encountered when investigating these interactions have resulted in an approach that studies saccharides through the enzymes that process them. Proteins and their function are often probed by manipulating the genes that encode them.
Timmer, M., Stocker, B., Seeberger, P.
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2009
Metabolomics is essentially the study of all low molecular weight molecules in a biological system under defined conditions. In glycomics, there is much potential to gain insight into the biosynthesis of novel glycoconjugate structures by probing the metabolome for substrates that are suspected, or known, to be involved in the biosynthetic processes ...
Soo, Evelyn C., Hui, Joseph P. M.
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Metabolomics is essentially the study of all low molecular weight molecules in a biological system under defined conditions. In glycomics, there is much potential to gain insight into the biosynthesis of novel glycoconjugate structures by probing the metabolome for substrates that are suspected, or known, to be involved in the biosynthetic processes ...
Soo, Evelyn C., Hui, Joseph P. M.
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Glycomics and Mass Spectrometry
Current Pharmaceutical Design, 2005Proteomics is closely associated with the modifications of the gene product such as the post-translational events that yield functionally active gene products. Among these, glycosylation represents a critically important post-translational modification and is a target for proteomic research.
Morelle, Willy, Michalski, Jean-Claude
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2009
The ability to quantitatively determine changes is an essential component of comparative glycomics. Multiple strategies are available by which this can be accomplished. These include label-free approaches and strategies where an isotopic label is incorporated into the glycans prior to analysis.
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The ability to quantitatively determine changes is an essential component of comparative glycomics. Multiple strategies are available by which this can be accomplished. These include label-free approaches and strategies where an isotopic label is incorporated into the glycans prior to analysis.
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Amplification and Preparation of Cellular O-Glycomes for Functional Glycomics
Analytical Chemistry, 2020Mucin-type O-glycans play key roles in many cellular processes, and they are often altered in human diseases. A major challenge in studying the role of O-glycans through functional O-glycomics is the absence of a complete repertoire of the glycans that comprise the human O-glycome. Here we describe a cellular O-glycome preparation strategy, Preparative
Zhonghua Li +11 more
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Separation technologies for glycomics
Journal of Chromatography B, 2002Progress in genome projects has provided us with fundamentals on genetic information; however, the functions of a large number of genes remain to be elucidated. To understand the in vivo functions of eukaryotic genes, it is essential to grasp the features of their post-translational modifications. Among them, protein glycosylation is a central issue to
Jun, Hirabayashi, Ken-ichi, Kasai
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Glycome profiling using modern glycomics technology: technical aspects and applications
Biological Chemistry, 2010AbstractGlycomics research has become indispensable in many research fields such as immunity, signal transduction and development. Moreover, changes in the glycosylation of proteins and lipids have been reported in several diseases including cancer.
Dieter, Vanderschaeghe +3 more
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2016
Glycomics is the comprehensive study of glycomes (the entire complement of sugars, whether free or present in more complex molecules of an organism), including genetic, physiologic, pathologic, and other aspects in living organisms. Carbohydrates being most abundant macromolecules are found in all organisms’ organs, tissues, and cells. They are present
Shahzad, M. Asif +3 more
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Glycomics is the comprehensive study of glycomes (the entire complement of sugars, whether free or present in more complex molecules of an organism), including genetic, physiologic, pathologic, and other aspects in living organisms. Carbohydrates being most abundant macromolecules are found in all organisms’ organs, tissues, and cells. They are present
Shahzad, M. Asif +3 more
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Oligosaccharide microarrays for glycomics
Trends in Biotechnology, 2003Glycomics is an emerging field that was proposed at the end of the 20th century as a new concept to follow genomics and proteomics. Studies on glycans are indispensable to define complex life systems and cell communities because all living organisms consist of diverse cells, which are covered with an abundance of heterogeneous carbohydrates.
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