Results 1 to 10 of about 56,998 (309)

The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity [PDF]

Molecules, 2013
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
Paul V. Murphy, Sabine André, Hans-Joachim Gabius   +2 more
doaj   +5 more sources

A Glycopeptide Mosaic Vaccine Elicits Robust Antitumor Immunity by Targeting Glycan Heterogeneity. [PDF]

JACS Au
Wu Y, Ma W, Jiang Y, Ling Y, Zhou Y, Guo Y, Hong S, Ding F, Zhang J, Li B, Liang H, Wang Z, Li Y, Li T, Cai H.   +14 more
europepmc   +2 more sources

EVALUATION OF USING EMPIRIC GLYCOPEPTIDES IN ACCORDANCE WITH THE IDSA GUIDELINE IN HEMATOLOGIC MALIGNANCY PATIENTS WITH FEBRILE NEUTROPENIA

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Background: This study aimed to evaluate the effects of the appropriate use of empiric glycopeptide therapy in hematologic malignancy patients with febrile neutropenia (FN).
Cumali Yalçın, Fahir Özkalemkaş, Vildan Özkocaman, Tuba Ersal, İbrahim Ethem Pınar, Bedrettin Orhan, Ömer Candar, Sinem Çubukçu, Tuba Güllü Koca, Merve Nur Akyol, Nevriye Gül Ada, Cüneyt Özakın, Esra Kazak, Halis Akalın, Rıdvan Ali   +14 more
doaj   +1 more source

Advanced assessment through intact glycopeptide analysis of Infliximab’s biologics and biosimilar

Frontiers in Molecular Biosciences, 2022
Characterization of therapeutic monoclonal antibodies (mAbs) represents a major challenge for analytical sciences due to their heterogeneity associated with post-translational modifications (PTMs).
Hyejin Kim, Hyejin Kim, Geul Bang, Geul Bang, Ye Eun Park, Moonhee Park, Jung Hoon Choi, Myung Jin Oh, Myung Jin Oh, Hyun Joo An, Hyun Joo An, Jong Shin Yoo, Jong Shin Yoo, Youngja Hwang Park, Youngja Hwang Park, Jin Young Kim, Heeyoun Hwang   +16 more
doaj   +1 more source

Synthesis of glycopeptides and glycopeptide conjugates

Organic & Biomolecular Chemistry, 2022
Synthetic glycopeptides are of key importance for unraveling the complexities of glycobiology. In this Review, the key approaches towards synthetic well-defined glycopeptides and glycopeptide conjugates are described.
Doelman, W., Kasteren, S.I. van
openaire   +3 more sources

Small and Equipped: the Rich Repertoire of Antibiotic Resistance Genes in Candidate Phyla Radiation Genomes

mSystems, 2021
Microbes belonging to Candidate Phyla Radiation (CPR) have joined the tree of life as a new branch, thanks to the intensive application of metagenomics and sequencing technologies.
Mohamad Maatouk, Ahmad Ibrahim, Jean-Marc Rolain, Vicky Merhej, Fadi Bittar   +4 more
doaj   +1 more source

ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum

Nanomaterials, 2021
Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases. For comprehensive characterization of their extreme structural complexity occurring in >50% of
Tiara Pradita, Yi-Ju Chen, Elias Gizaw Mernie, Sharine Noelle Bendulo, Yu-Ju Chen   +4 more
doaj   +1 more source

Genome-Guided Discovery of Natural Products through Multiplexed Low-Coverage Whole-Genome Sequencing of Soil Actinomycetes on Oxford Nanopore Flongle

mSystems, 2021
Genome mining is an important tool for discovery of new natural products; however, the number of publicly available genomes for natural product-rich microbes such as actinomycetes, relative to human pathogens with smaller genomes, is small.
Rahim Rajwani, Shannon I. Ohlemacher, Gengxiang Zhao, Hong-Bing Liu, Carole A. Bewley   +4 more
doaj   +1 more source

Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1—7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers

Pharmaceutics, 2021
The peptide hormone Angiotensin (1—7), Ang (1—7) or (Asp-Arg-Val-Tyr-Ile-His-Pro), is an essential component of the renin–angiotensin system (RAS) peripherally and is an agonist of the Mas receptor centrally.
Wafaa Alabsi, Maria F. Acosta, Fahad A. Al-Obeidi, Meredith Hay, Robin Polt, Heidi M. Mansour   +5 more
doaj   +1 more source

Improving Confidence for the Identification of N-Linked Intact Glycopeptides Based on the Precursor Feature [PDF]

Zhipu Xuebao, 2023
As a common and heterogeneous post-translational modification (PTM), glycosylation takes part in a wide variety of biological processes. Precision analysis of glycosylation is of great value for the determination of their functional roles and the ...
FANG Zheng;QIN Hong-qiang;YE Ming-liang
doaj   +1 more source