Results 131 to 140 of about 40,816 (237)

Site-Specific Glycoprofiles of HDL-Associated ApoE are Correlated with HDL Functional Capacity and Unaffected by Short-Term Diet. [PDF]

, 2019
Since high-density lipoprotein (HDL) glycoprofiles are associated with HDL functional capacity, we set out to determine whether diet can alter the glycoprofiles of key HDL-associated proteins, including ApoE, a potent driver of chronic disease risk.
Beals, Elizabeth, Lebrilla, Carlito B, Li, Qiongyu, Rhodes, Chris H, Sacchi, Romina, Sawrey-Kubicek, Lisa, Wong, Maurice, Zhu, Chenghao, Zivkovic, Angela M   +8 more
core  

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

A Streamlined Synthesis of Adenosine Vinylsulfonamide Probes for Aminoacyl‐AMP Mimicry in NRPS

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
A concise three‐step synthesis enables access to amino acid‐derived adenosine vinylsulfonamide (AVS) probes under mild conditions. Ba(OH)2‐mediated coupling suppresses epimerization, affording stereochemically defined probes that covalently capture nonribosomal peptide synthetase (NRPS) thioesterification states. LC–MS/MS confirms functional engagement
Naoto Haraguchi, Arisa Suto, Takashi Matsui, Yoshio Kodera, Yoshikazu Tanaka, Ryo Tanifuji, Hiroki Oguri   +6 more
wiley   +1 more source

Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Corallopyronin A (CorA), a natural alpha‐pyrone antibiotic, penetrates Staphylococcus aureus biofilms and inhibits RNA polymerase. This work demonstrates CorA's superior efficacy compared to rifampicin and dalbavancin in reducing viable loads in biofilms both in vitro and in vivo. Graphic created in https://BioRender.com.
Stefania De Benedetti, Nikolay Krasimirov Kirilov, Haoxuan Zeng, Carolin Ade, Isabel Bodenstein, Maximilian Förster, Noran Abdel‐Wadood, Ahmad Aljohmani, Gabriela Krasteva‐Christ, Daniela Yildiz, Sabryna Junker, Syeda Javariya Khalid, Katharina Rox, Hedda Schrey, Miriam Große, Andrea Schiefer, Sören Leif Becker, Kenneth Pfarr, Achim Hoerauf, Markus Bischoff, Mathias Müsken, Tanja Schneider   +21 more
wiley   +1 more source

Vancomycin levels for Bayesian dose-optimization in critical care: a prospective cohort study

Frontiers in Medicine
BackgroundVancomycin dosing in critically ill patients typically requires monitoring the area under the concentration-time curve/minimum inhibitory concentration (AUC/MIC), often using at least two vancomycin levels (VLs).
Natalia Dreyse, Natalia Dreyse, Nicole Salazar, Jose M. Munita, Jordi Rello, Jordi Rello, Jordi Rello, René López, René López   +8 more
doaj   +1 more source

Glycopeptide resistance in enterococci [PDF]

, 2010
The selective pressure resulting from the extensive use of antibiotics over the last 50 years has led to the emergence of bacterial resistance and to the dissemination of resistance genes among pathogenic microorganisms.
Félix Claverie-Martín, Sebastián Méndez-Álvarez, Xiomara Pérez-Hernández   +2 more
core   +2 more sources

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology
Liver and pancreatic cancers are difficult to detect early, leading to high mortality rates. Blood‐based diagnostics present a viable alternative for earlier detection, potentially improving survival rates.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
doaj   +1 more source

Consumption of antibiotics at St Luke’s Hospital : a critical factor behind the local prevalence of antimicrobial resistance? [PDF]

, 2006
The intensity of antibiotic use in hospital settings is recognised as possibly the most important factor for the selection of antimicrobial resistance. Hospitals are therefore being encouraged to undertake surveillance and benchmarking of antimicrobial ...
Borg, Michael Angelo, Zarb, Peter
core  

Proteolytic release and partial characterization of human sperm-surface glycopeptides

Brazilian Journal of Medical and Biological Research, 1997
Sperm-surface glycopeptides were obtained from intact sperm membranes after proteolytic release by different enzymatic treatments such as autoproteolysis, trypsin, papain and pronase.
Tortorella H., Konrath R.A., Mazzini M.N., Brandelli A.   +3 more
doaj  

Evaluation of Susceptibility to Glycopeptides in Oxacillin Resistant Staphylococcus aureus Strains

Kasmera, 2012
The decrease in susceptibility to glycopeptides by oxacillin resistant Staphylococcus aureus (ORSA) has become a current problem. Objective: To evaluate susceptibility to glycopeptides in ORSA strains isolated in the University Hospital, Maracaibo ...
Maribel Castellano González, Armindo Perozo Mena, Ana González   +2 more
doaj