Results 111 to 120 of about 26,625 (243)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

CSF‐Compartmentalized Antibody Glycoprofiles in NMDAR Encephalitis Associate with Etiology and Functional Recovery

Annals of Neurology, Volume 99, Issue 6, Page 1468-1479, June 2026.
Objective To characterize Fc‐glycosylation profiles in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARe) and assess their association with antibody compartmentalization (cerebrospinal fluid [CSF] vs serum), disease triggers (viral, tumor‐related or idiopathic), and 1‐year outcomes.
Laura Marmolejo, Claudia Papi, Chiara Milano, Esther Aguilar, Estibaliz Maudes, Ivana Duvnjak Orešković, Jerko Štambuk, Maja Pučić‐Baković, Gemma Olivé‐Cirera, Elianet Fonseca, Mar Guasp, Eugenia Martinez‐Hernandez, Helena Ariño, Takahiro Iizuka, Thais Armangué, Josep Dalmau, Marianna Spatola   +16 more
wiley   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Prediction of Collision-Induced Dissociation Spectra of Common N-Glycopeptides for Glycoform Identification

, 2016
Confident identification of the glycan moieties in glycopeptides by collision-induced dissociation (CID) requires accurate prediction of the CID spectrum of the glycopeptides.
Zhongqi Zhang (1319571), Bhavana Shah (1886518)   +1 more
core   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

MS analysis of sialylation of GalNAcosylated synthetic HR glycopeptides (sHR) by ST6GalNAcI.

, 2014
(A) Acceptor sHR glycopeptides for ST6GalNAcI with 3 to 7 GalNAc residues were generated by recombinant GalNAc-T2 after a 15-min reaction. (B) sHR glycopeptides produced after over-night reaction with ST6GalNAcI.
Jan Novak (156878), Yukio Yuzawa (576198), Matthew B. Renfrow (261090), Knud Poulsen (50933), Zina Moldoveanu (488060), Bruce A. Julian (156876), Yoshiyuki Hiki (576197), Stacy D. Hall (576196), Mogens Kilian (50932), Kazuo Takahashi (182663), Milan Raska (576194), Milada Stuchlova Horynova (576195)   +11 more
core   +1 more source

Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Vancomycin‐induced gut dysbiosis depletes butyrate‐producing bacteria, reduces colonic butyrate, disrupts the intestinal barrier, and exacerbates allergic rhinitis (AR). The colon‐targeted butyrate precursor butyrylated starch reverses this pathological cascade, restores immune homeostasis, and alleviates AR, providing a novel dietary intervention for ...
Yuxi Lin, Qingqing Xu, Siyi Tang, Jingmin Chen, Xing Lin, Yang Liu, Yuanteng Xu   +6 more
wiley   +1 more source

Large-scale characterization of intact N-glycopeptides using an automated glycoproteomic method

, 2014
The detailed characterization of site-specific glycosylation requires the identification of glycan composition and specific attachment sites on proteins, which need the identification of intact glycopeptides by mass spectrometry.
DanielFigeys, 叶明亮, Seebun, Deeptee, Figeys, Daniel, Zou, Hanfa, Ye, Mingliang, Chen, Rui, Cheng, Kai   +7 more
core   +1 more source

The Effectiveness of Linezolid and Teicoplanin for Managing Infections After Burn Injuries: A Retrospective Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Gram‐positive infections in burn patients present significant treatment challenges. This study compared the efficacy and safety of linezolid vs. teicoplanin for managing such infections in a clinical setting. Methods We conducted a retrospective study involving 77 burn patients with confirmed Gram‐positive infections at ...
Abolfazl Zendehdel, Maryam Roham, Sanam Soltani, Amirali Jahanshahi, Somayeh Heidarizadi   +4 more
wiley   +1 more source

Vancomycin levels for Bayesian dose-optimization in critical care: a prospective cohort study

Frontiers in Medicine
BackgroundVancomycin dosing in critically ill patients typically requires monitoring the area under the concentration-time curve/minimum inhibitory concentration (AUC/MIC), often using at least two vancomycin levels (VLs).
Natalia Dreyse, Natalia Dreyse, Nicole Salazar, Jose M. Munita, Jordi Rello, Jordi Rello, Jordi Rello, René López, René López   +8 more
doaj   +1 more source