Results 21 to 30 of about 20,845 (201)

Determination of the safety of glycopeptides lactic acid bacteria in laboratory animals

Фармакокинетика и Фармакодинамика, 2019
The study of acute toxicity and allergenity glycopeptides lactic acid bacteria in mice and rabbits. At the present level of physical, chemical and biological pollution of the environment, domestic and farm animals in no less, if not more than people ...
O. V. Sofronova, L. L. Polyakova, A. N. Ovcharova   +2 more
doaj   +1 more source

Cephalosporin-Glycopeptide Combinations for Use against Clinical Methicillin-Resistant Staphylococcus aureus Isolates: Enhanced In vitro Antibacterial Activity

Frontiers in Microbiology, 2017
The empirical combination of both a beta-lactam and glycopeptide to counter potential staphylococcal pathogens may improve the clinical outcomes for cases of Staphylococcus aureus bacteremia.
Hung-Jen Tang, Hung-Jen Tang, Chih-Cheng Lai, Chi-Chung Chen, Chun-Cheng Zhang, Tzu-Chieh Weng, Wen-Liang Yu, Wen-Liang Yu, Hung-Jui Chen, Yu-Hsin Chiu, Wen-Chien Ko, Wen-Chien Ko, Yin-Ching Chuang, Yin-Ching Chuang   +13 more
doaj   +1 more source

Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints

Angewandte Chemie, EarlyView.
We demonstrate a new platform for antimicrobial peptide identification by combining polydiacetylene, hyperspectral imaging, and deep learning. The trained model classifies distinct spectral fingerprints into 14 peptide classes with 96.79% accuracy, revealing previously hidden molecular information beyond conventional colorimetric sensing.
Jiali Chen, Che‐Lun Chin, Qingzhen Zhu, Ling Chao, Kaori Sugihara   +4 more
wiley   +2 more sources

Comparison of Different HILIC Stationary Phases in the Separation of Hemopexin and Immunoglobulin G Glycopeptides and Their Isomers

Molecules, 2020
Protein glycosylation analysis is challenging due to the structural variety of complex conjugates. However, chromatographically separating glycans attached to tryptic peptides enables their site-specific characterization.
Katarina Molnarova, Petr Kozlík
doaj   +1 more source

Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus

Antibiotics, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality.
Harshad Lade, Hwang-Soo Joo, Jae-Seok Kim   +2 more
doaj   +1 more source

TiO2 Simultaneous Enrichment, On-Line Deglycosylation, and Sequential Analysis of Glyco- and Phosphopeptides

Frontiers in Chemistry, 2021
Reversible protein glycosylation and phosphorylation tightly modulate important cellular processes and are closely involved in pathological processes in a crosstalk dependent manner.
Cheng Chen, Cheng Chen, Xiaofei Zhang, Xuefang Dong, Han Zhou, Xiuling Li, Xiuling Li, Xinmiao Liang, Xinmiao Liang   +8 more
doaj   +1 more source

Characterization of the Streptomyces coelicolor Glycoproteome Reveals Glycoproteins Important for Cell Wall Biogenesis

mBio, 2019
The physiological role of protein O-glycosylation in prokaryotes is poorly understood due to our limited knowledge of the extent of their glycoproteomes.
Tessa Keenan, Adam Dowle, Rachel Bates, Margaret C. M. Smith   +3 more
doaj   +1 more source

Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis

Frontiers in Immunology
Systemic sclerosis (SSc) is a perplexing autoimmune disorder, characterized by mysterious causes, high mortality rates, and a lack of effective treatments.
Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang   +10 more
doaj   +1 more source

A bivalent glycopeptide to target two putative carbohydrate binding sites on FimH

Beilstein Journal of Organic Chemistry, 2010
FimH is a mannose-specific bacterial lectin found on type 1 fimbriae with a monovalent carbohydrate recognition domain (CRD) that is known from X-ray studies.
Thisbe K. Lindhorst, Kathrin Bruegge, Andreas Fuchs, Oliver Sperling   +3 more
doaj   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source