Results 21 to 30 of about 29,057 (236)

Integration of high-pH fractionation and cotton-HILIC enrichment approaches for analyzing N-glycopeptides

Advances in Sample Preparation, 2023
Glycosylation, a prevalent post-translational modification, plays a significant role in diverse biological processes and exhibits associations with various diseases, including cancer.
Nabil Tahhan, Sena Aksoy, Haci Mehmet Kayili, Bekir Salih   +3 more
doaj   +1 more source

Acquisition of Daptomycin Resistance by Enterococcus faecium Confers Collateral Sensitivity to Glycopeptides

Frontiers in Microbiology, 2022
Daptomycin is a last-line antibiotic used in the treatment of multidrug-resistant Enterococcus faecium infections. Alarmingly, daptomycin-resistant E. faecium isolates have emerged.
Weiliang Zeng, Luozhu Feng, Changrui Qian, Tao Chen, Sipei Wang, Ying Zhang, Xiangkuo Zheng, Lingbo Wang, Shixing Liu, Tieli Zhou, Yao Sun   +10 more
doaj   +1 more source

Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting

Communications Biology, 2021
Mapping multiple glycan species to the same peptide and location from shared retention time of glycopeptides with MS and HPLC, Chalk, Greenland et al. construct a detailed mass-retention time database for Spike protein glycopeptides. This allows any mass
Rod Chalk, William E. P. Greenland, Tiago Moreira, Jesse Coker, Shubhashish M. M. Mukhopadhyay, Eleanor Williams, Charlotte Manning, Tina Bohstedt, Rama McCrorie, Alejandra Fernandez-Cid, Nicola A. Burgess-Brown   +10 more
doaj   +1 more source

Chemical Synthesis of Glycopeptides containing l‑Arabinosylated Hydroxyproline and Sulfated Tyrosine [PDF]

, 2023
Post-translationally modified peptides are important regulating molecules for living organisms. Here, we report the stereoselective total synthesis of β-1,2-linked l-arabinosylated Fmoc-protected hydroxyproline building blocks and their incorporation ...
Bauke Albada (1781323), Albada, Bauke, van de Sande, Jasper W., Jasper, van de Sande, Jasper W. van de Sande (14790340), Bauke, Albada   +5 more
core   +2 more sources

Fragmentation characteristics of glycopeptides [PDF]

, 2013
Mass spectrometric analysis of glycopeptides is an emerging strategy for analysis of glycosylation patterns. Here we present an approach using energy resolved collision induced decomposition (CID) spectra to determine structural features of glycopeptides.
Jekő, Anita, Drahos, László, Révész, Ágnes, Krenyácz, Judit, Tóth, Eszter, Ozohanics, Olivér, Vékey, Károly   +6 more
core   +1 more source

Precursor ion scanning for detection and structural characterization of heterogeneous glycopeptide mixtures [PDF]

, 2002
The structure of N-linked glycans is determined by a complex, anabolic, intracellular pathway but the exact role of individual glycans is not always clear.
Gill, A C, Lilley, Kathryn, Ritchie, Mark A, Deery, Michael J, Lilley, K, Gill, Andrew C, Ritchie, M A, Deery, M J   +7 more
core   +1 more source

Synthesis and Biological Evaluation of Well-Defined M6P(n)-Modified Glycopeptides for Targeted Protein Degradation. [PDF]

Chemistry
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Lenartowicz P, Langenbach JH, Voloshyna N, Aidukas D, Brouwer AJ, Kruijtzer JAW, Boons GJ.   +6 more
europepmc   +2 more sources

Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis [PDF]

, 2020
The recently described O-glycoprotease OpeRATOR presents exciting opportunities for O-glycoproteomics. This bacterial enzyme purified from Akkermansia (Sp).
Nicholas, Riley, Carolyn, Bertozzi, Stacy, Malaker   +2 more
core   +2 more sources

Glycopeptide Hypersensitivity and Adverse Reactions

Pharmacy, 2020
Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most ...
Vanthida Huang, Nicola A. Clayton, Kimberly H. Welker   +2 more
doaj   +1 more source

‐Glycopeptides Found in Serum [PDF]

, 2018
Purpose Experimental design There are no blood biomarkers to detect early-stage oral cavity squamous cell carcinoma (OSCC) prior to clinical signs. Most OSCC incidence is associated with significant morbidity and poor survival.
Tohmola, Tiialotta, Saraswat, Shruti, Mayank Saraswat, Suvi Renkonen, Saraswat, S, Antti Mäkitie, Sakari Joenväärä, Renkonen, Suvi, Saraswat, M, Renkonen, S, Joenvaara, S, Shruti Saraswat, Tiialotta Tohmola, Tohmola, T, Mäkitie, Antti, Makitie, A, Saraswat, Mayank, Joenväärä, Sakari, Dickinson, Amy, Dickinson, A, Amy Dickinson   +20 more
core   +1 more source