Results 31 to 40 of about 26,625 (243)

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Comparison of Different HILIC Stationary Phases in the Separation of Hemopexin and Immunoglobulin G Glycopeptides and Their Isomers

Molecules, 2020
Protein glycosylation analysis is challenging due to the structural variety of complex conjugates. However, chromatographically separating glycans attached to tryptic peptides enables their site-specific characterization.
Katarina Molnarova, Petr Kozlík
doaj   +1 more source

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus

Antibiotics, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality.
Harshad Lade, Hwang-Soo Joo, Jae-Seok Kim   +2 more
doaj   +1 more source

TiO2 Simultaneous Enrichment, On-Line Deglycosylation, and Sequential Analysis of Glyco- and Phosphopeptides

Frontiers in Chemistry, 2021
Reversible protein glycosylation and phosphorylation tightly modulate important cellular processes and are closely involved in pathological processes in a crosstalk dependent manner.
Cheng Chen, Cheng Chen, Xiaofei Zhang, Xuefang Dong, Han Zhou, Xiuling Li, Xiuling Li, Xinmiao Liang, Xinmiao Liang   +8 more
doaj   +1 more source

Precursor ion scanning for detection and structural characterization of heterogeneous glycopeptide mixtures

, 2002
The structure of N-linked glycans is determined by a complex, anabolic, intracellular pathway but the exact role of individual glycans is not always clear.
Gill, A C, Lilley, Kathryn, Ritchie, Mark A, Deery, Michael J, Lilley, K, Gill, Andrew C, Ritchie, M A, Deery, M J   +7 more
core   +1 more source

Retention mechanism and enrichment of glycopeptides on titanium dioxide

, 2013
A uniform method for the facile and selective enrichment of glycopeptides with titanium dioxide (TiO2) is presented. Retention mechanisms between glycopeptides and TiO2 were explored by checking the influence of acetonitrile content, NH3 center dot H2O ...
Yu, Long, 李秀玲, Sheng, Qianying, Ke, Yanxiong, Liang, Xinmiao, Li, Xiuling, 梁鑫淼, Yin, Wei   +7 more
core   +1 more source

Characterization of the Streptomyces coelicolor Glycoproteome Reveals Glycoproteins Important for Cell Wall Biogenesis

mBio, 2019
The physiological role of protein O-glycosylation in prokaryotes is poorly understood due to our limited knowledge of the extent of their glycoproteomes.
Tessa Keenan, Adam Dowle, Rachel Bates, Margaret C. M. Smith   +3 more
doaj   +1 more source

Efficient enrichment of glycopeptides using phenylboronic acid polymer brush modified silica microspheres

, 2014
For the development of rapid glycopeptide enrichment materials, conventional monolayer phenylboronic acid (PBA) based materials inevitably encounter many problems, such as low loading efficiency, long incubation time, and unsatisfactory selectivity ...
Wang, Shutao, Liang, Xinmiao, Li, Xiuling, 梁鑫淼, Liu, Hongliang, Qing, Guangyan   +5 more
core   +1 more source

Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis

Frontiers in Immunology
Systemic sclerosis (SSc) is a perplexing autoimmune disorder, characterized by mysterious causes, high mortality rates, and a lack of effective treatments.
Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang   +10 more
doaj   +1 more source