Results 31 to 40 of about 29,057 (236)

COMPARATIVE ANALYSIS OF THE ACTIVITY OF GLYCOPEPTIDES AND LINEZOLID AGAINST NOSOCOMIAL STRAINS OF GRAM-POSITIVE MICROORGANISMS ISOLATED FROM CANCER PATIENT

Сибирский онкологический журнал, 2021
The purpose of the study: to compare the activity of vancomycin, teicoplanin and linezolid and to determine their place in the current treatment of nosocomial infections caused by gram-positive microflora.Material and Methods.
N. V. Dmitrieva, I. N. Petukhova, Z. V. Grigoryevskaya, N. S. Bagirova, I. V. Tereshchenko, I. A. Klyuchnikova, S. A. Dyakova   +6 more
doaj   +1 more source

Simultaneous enrichment and sequential separation of glycopeptides and phosphopeptides with poly-histidine functionalized microspheres

Frontiers in Bioengineering and Biotechnology, 2022
Protein phosphorylation and glycosylation coordinately regulate numerous complex biological processes. However, the main methods to simultaneously enrich them are based on the coordination interactions or Lewis acid-base interactions, which suffer from ...
Danyi Shang, Danyi Shang, Cheng Chen, Cheng Chen, Xuefang Dong, Yun Cui, Yun Cui, Zichun Qiao, Zichun Qiao, Xiuling Li, Xiuling Li, Xinmiao Liang, Xinmiao Liang   +12 more
doaj   +1 more source

Prediction of Intact N-Glycopeptide Retention Time Windows in Hydrophilic Interaction Liquid Chromatography

Molecules, 2022
Analysis of protein glycosylation is challenging due to micro- and macro-heterogeneity of the attached glycans. Hydrophilic interaction liquid chromatography (HILIC) is a mode of choice for separation of intact glycopeptides, which are inadequately ...
Petr Kozlik, Katarina Molnarova, Tomas Jecmen, Tomas Krizek, Zuzana Bosakova   +4 more
doaj   +1 more source

Evaluating the Performance of 193 nm Ultraviolet Photodissociation for Tandem Mass Tag Labeled Peptides

Analytica, 2021
Despite the successful application of tandem mass tags (TMT) for peptide quantitation, missing reporter ions in higher energy collisional dissociation (HCD) spectra remains a challenge for consistent quantitation, especially for peptides with labile post-
Mowei Zhou, Ju Yeon Lee, Gun Wook Park, Neha Malhan, Tao Liu, Jared B. Shaw   +5 more
doaj   +1 more source

Solid-Phase Synthesis and Evaluation of Glycopeptide Fragments from Rat Epididymal Cysteine-Rich Secretory Protein-1 (Crisp-1) ‡

Molecules, 2010
Three 18-residue peptides with the sequence Glp-Asp-Thr-Thr-Asp-Glu-Trp-Asp-Arg-Asp-Leu-Glu-Asn-Leu-Ser-Thr-Thr-Lys, taken from the N-terminus of the rat epididymal cysteine-rich secretory protein (Crisp-1) that is important in the fertilization process,
George Barany, David W. Hamilton, Mian Liu   +2 more
doaj   +1 more source

Retention mechanism and enrichment of glycopeptides on titanium dioxide

, 2013
A uniform method for the facile and selective enrichment of glycopeptides with titanium dioxide (TiO2) is presented. Retention mechanisms between glycopeptides and TiO2 were explored by checking the influence of acetonitrile content, NH3 center dot H2O ...
Yu, Long, 李秀玲, Sheng, Qianying, Ke, Yanxiong, Liang, Xinmiao, Li, Xiuling, 梁鑫淼, Yin, Wei   +7 more
core   +1 more source

Efficient enrichment of glycopeptides using phenylboronic acid polymer brush modified silica microspheres

, 2014
For the development of rapid glycopeptide enrichment materials, conventional monolayer phenylboronic acid (PBA) based materials inevitably encounter many problems, such as low loading efficiency, long incubation time, and unsatisfactory selectivity ...
Wang, Shutao, Liang, Xinmiao, Li, Xiuling, 梁鑫淼, Liu, Hongliang, Qing, Guangyan   +5 more
core   +1 more source

Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis

Frontiers in Immunology
Systemic sclerosis (SSc) is a perplexing autoimmune disorder, characterized by mysterious causes, high mortality rates, and a lack of effective treatments.
Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang   +10 more
doaj   +1 more source

Selective enrichment of glycopeptides for mass spectrometry analysis using C18 fractionation and titanium dioxide chromatography

, 2011
Selective enrichment of glycopeptides for mass spectrometry analysis using C18 fractionation and titanium dioxide chromatographyComprehensive glycoprotein characterization based on mass spectrometry (MS) is challenging because of low concentration of ...
Sheng, Qianying, Liang, Qi, Yan, Jingyu, Zhang, Bo, Liang, Xinmiao, Li, Xiuling, 梁鑫淼   +6 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source