Results 1 to 10 of about 605,903 (239)

Characterizing Intact IgA2 Antibody and Its Size Variants Using Native Mass Spectrometry and a Tandem MS-based Charge Reduction Approach [PDF]

Zhipu Xuebao, 2022
Characterization of protein structures at multiple levels plays an essential role in study on protein functions. Structural analysis at the intact protein or intact complex level allows access of information on aspects including level of post ...
CHEN Qing-rong;CHAIHU Ling-xiao;CHEN Tao;WANG Guan-bo
doaj   +1 more source

New Human Follitropin Preparations: How Glycan Structural Differences May Affect Biochemical and Biological Function and Clinical Effect

Frontiers in Endocrinology, 2021
It is well accepted that pituitary follitropin is secreted into the circulation as a mixture of variants, which differ not in primary structure but rather at the level of glycosylation.
James A. Dias, Alfredo Ulloa-Aguirre
doaj   +1 more source

Recent Developments in Deciphering the Biological Role of Plant Complex N-Glycans

Frontiers in Plant Science, 2022
Asparagine (N)-linked protein glycosylation is a ubiquitous co- and posttranslational modification which has a huge impact on the biogenesis and function of proteins and consequently on the development, growth, and physiology of organisms.
Richard Strasser
doaj   +1 more source

Single Nucleotide Variants of the Human TIM-1 IgV Domain with Reduced Ability to Promote Viral Entry into Cells

Viruses, 2022
Human T-cell immunoglobulin mucin 1 (hTIM-1) is known to promote cellular entry of enveloped viruses. Previous studies suggested that the polymorphisms of hTIM-1 affected its function.
Takanari Hattori, Takeshi Saito, Hiroko Miyamoto, Masahiro Kajihara, Manabu Igarashi, Ayato Takada   +5 more
doaj   +1 more source

A Bivalent Human Adenovirus Type 5 Vaccine Expressing the Rabies Virus Glycoprotein and Canine Distemper Virus Hemagglutinin Protein Confers Protective Immunity in Mice and Foxes

Frontiers in Microbiology, 2020
The development of a safe and efficient multivalent vaccine has great prospects for application. Both rabies virus (RABV) and canine distemper virus (CDV) are highly infectious antigens, causing lethal diseases in domestic dogs and other carnivores ...
Lina Yan, Zhongxin Zhao, Xianghong Xue, Wenwen Zheng, Tong Xu, Lele Liu, Li Tian, Xianwei Wang, Hongbin He, Xuexing Zheng   +9 more
doaj   +1 more source

Extensins: Self-Assembly, Crosslinking, and the Role of Peroxidases

Frontiers in Plant Science, 2021
The extensin (EXT) network is elaborated by the covalent intermolecular crosslinking of EXT glycoprotein monomers, and its proper assembly is important for numerous aspects of basic wall architecture and cellular defense.
John W. Mishler-Elmore, Yadi Zhou, Abhijit Sukul, Mercedes Oblak, Li Tan, Ahmed Faik, Ahmed Faik, Michael A. Held, Michael A. Held   +8 more
doaj   +1 more source

Extracellular Matrix of Echinoderms

Marine Drugs, 2023
This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko   +1 more
doaj   +1 more source

Identification of a Neutralizing Epitope on TOSV Gn Glycoprotein

Vaccines, 2021
Emerging and re-emerging viral infections have been an important public health problem in recent years. We focused our attention on Toscana virus (TOSV), an emergent neurotropic negative-strand RNA virus of the Phenuiviridae family.
Claudia Gandolfo, Shibily Prathyumn, Chiara Terrosi, Gabriele Anichini, Gianni Gori Savellini, Davide Corti, Luisa Bracci, Antonio Lanzavecchia, Gleyder Roman-Sosa, Maria Grazia Cusi   +9 more
doaj   +1 more source

Point Mutations in the Glycoprotein Ectodomain of Field Rabies Viruses Mediate Cell Culture Adaptation through Improved Virus Release in a Host Cell Dependent and Independent Manner

Viruses, 2021
Molecular details of field rabies virus (RABV) adaptation to cell culture replication are insufficiently understood. A better understanding of adaptation may not only reveal requirements for efficient RABV replication in cell lines, but may also provide ...
Sabine Nitschel, Luca M. Zaeck, Madlin Potratz, Tobias Nolden, Verena te Kamp, Kati Franzke, Dirk Höper, Florian Pfaff, Stefan Finke   +8 more
doaj   +1 more source

The Roles of Ebola Virus Soluble Glycoprotein in Replication, Pathogenesis, and Countermeasure Development

Viruses, 2019
Ebola virus (EBOV) is a highly lethal pathogen that has caused several outbreaks of severe hemorrhagic fever in humans since its emergence in 1976. The EBOV glycoprotein (GP1,2) is the sole viral envelope protein and a major component of immunogenicity ...
Wenjun Zhu, Logan Banadyga, Karla Emeterio, Gary Wong, Xiangguo Qiu   +4 more
doaj   +1 more source