Results 11 to 20 of about 955,216 (365)

SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants

Frontiers in Immunology, 2021
Coronavirus 19 Disease (COVID-19) originating in the province of Wuhan, China in 2019, is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), whose infection in humans causes mild or severe clinical manifestations that mainly
Daniel Martínez-Flores, Jesús Zepeda-Cervantes, Adolfo Cruz-Reséndiz, Sergio Aguirre-Sampieri, A. Sampieri, L. Vaca   +5 more
semanticscholar   +1 more source

Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26

Emerging Microbes and Infections, 2020
The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free ...
Naveen Vankadari, J. Wilce
semanticscholar   +1 more source

Extracellular Matrix of Echinoderms

Marine Drugs, 2023
This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko   +1 more
doaj   +1 more source

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

Genome Medicine, 2020
SARS-CoV-2 is a recently emerged respiratory pathogen that has significantly impacted global human health. We wanted to rapidly characterise the transcriptomic, proteomic and phosphoproteomic landscape of this novel coronavirus to provide a fundamental ...
A. Davidson, M. Williamson, Sebastian Lewis, D. Shoemark, M. Carroll, K. Heesom, M. Zambon, J. Ellis, Philip A. Lewis, J. Hiscox, D. Matthews   +10 more
semanticscholar   +1 more source

Identification of a Neutralizing Epitope on TOSV Gn Glycoprotein

Vaccines, 2021
Emerging and re-emerging viral infections have been an important public health problem in recent years. We focused our attention on Toscana virus (TOSV), an emergent neurotropic negative-strand RNA virus of the Phenuiviridae family.
Claudia Gandolfo, Shibily Prathyumn, Chiara Terrosi, Gabriele Anichini, Gianni Gori Savellini, Davide Corti, Luisa Bracci, Antonio Lanzavecchia, Gleyder Roman-Sosa, Maria Grazia Cusi   +9 more
doaj   +1 more source

Point Mutations in the Glycoprotein Ectodomain of Field Rabies Viruses Mediate Cell Culture Adaptation through Improved Virus Release in a Host Cell Dependent and Independent Manner

Viruses, 2021
Molecular details of field rabies virus (RABV) adaptation to cell culture replication are insufficiently understood. A better understanding of adaptation may not only reveal requirements for efficient RABV replication in cell lines, but may also provide ...
Sabine Nitschel, Luca M. Zaeck, Madlin Potratz, Tobias Nolden, Verena te Kamp, Kati Franzke, Dirk Höper, Florian Pfaff, Stefan Finke   +8 more
doaj   +1 more source

The Roles of Ebola Virus Soluble Glycoprotein in Replication, Pathogenesis, and Countermeasure Development

Viruses, 2019
Ebola virus (EBOV) is a highly lethal pathogen that has caused several outbreaks of severe hemorrhagic fever in humans since its emergence in 1976. The EBOV glycoprotein (GP1,2) is the sole viral envelope protein and a major component of immunogenicity ...
Wenjun Zhu, Logan Banadyga, Karla Emeterio, Gary Wong, Xiangguo Qiu   +4 more
doaj   +1 more source

Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons

Nature Protocols, 2010
Recombinant rabies viruses rendered replication-deficient by the deletion of their envelope glycoprotein gene are useful tools for neuroscientists, permitting (1) extraordinarily high transgene expression levels within neurons, (2) retrograde infection ...
Citation Wickersham, I. R, H. Sullivan, H. Sebastian   +3 more
semanticscholar   +1 more source

The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens

Frontiers in Immunology, 2020
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public health and imposes a severe burden on the entire human society.
L. Duan, Qianqian Zheng, Hongxia Zhang, Y. Niu, Yunwei Lou, Hui Wang   +5 more
semanticscholar   +1 more source

A Method for Determining the Content of Glycoproteins in Biological Samples

Molecules, 2016
The glycoprotein purified from the mycelium extract of Tremella fuciformis was marked with iodine through the iodine substitution reaction. The content of iodine, which is indicative of the amount of the marked tremella glycoprotein (ITG), was detected ...
Yang Gao, Duoduo Xu, Hongyue Li, Xianling Yang, Mingxing Wang, Qipin Gao   +5 more
doaj   +1 more source