Structure analysis of biologically important prokaryotic glycopolymers [PDF]
, 2013 Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria +1 more
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Envelope Glycoprotein of Arenaviruses [PDF]
Viruses, 2012 Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for the development of efficacious therapeutics an urgent need.
Burri, D.J. +3 more
openaire +5 more sources
Extracellular Matrix of Echinoderms
Marine Drugs, 2023 This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov +1 more
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Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. [PDF]
, 1991 Lymphocyte attachment to high endothelial venules within lymph nodes is mediated by the peripheral lymph node homing receptor (pnHR), originally defined on mouse lymphocytes by the MEL-14 mAb.
Fennie, C +4 more
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Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]
, 2017 The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G. +4 more
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
mAbs, 2020 Glycosylation is a common post-translational modification and critical quality attribute that can modulate the efficacy of therapeutic proteins.
Zaneer Segu +5 more
doaj +1 more source
Herpes Simplex Virus 1 Entry Glycoproteins Form Complexes before and during Membrane Fusion
mBio, 2022 Herpesviruses—ubiquitous pathogens that cause persistent infections—have some of the most complex cell entry mechanisms. Entry of the prototypical herpes simplex virus 1 (HSV-1) requires coordinated efforts of 4 glycoproteins, gB, gD, gH, and gL.
Zemplen Pataki +2 more
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Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative [PDF]
Journal of Translational Medicine (2015) 13:124, 2016 Background: In this paper, we present an approach to understand how the basic, clinical and patent knowledge on Ebola is organized and intercommunicated and what leading factor could be shaping the evolution of the knowledge translation process for this disease.
arxiv +1 more source
The use of chitin binding proteins for glycoprotein analysis [PDF]
, 2009 The focus of the pharmaceutical industry has dramatically shifted in the past number of years. Traditional drugs were synthesised using chemical reactions have been replaced by recombinant glycoprotein molecules.
Larragy, Ruth +2 more
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