Results 81 to 90 of about 698,632 (367)

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Preclinical Safety Assessment of the EBS-LASV Vaccine Candidate against Lassa Fever Virus

Vaccines
There are currently no prophylactic vaccines licensed to protect against Lassa fever caused by Lassa virus (LASV) infection. The Emergent BioSolutions (EBS) vaccine candidate, EBS-LASV, is being developed for the prevention of Lassa fever.
Demetrius Matassov, Lisa Evans DeWald, Stefan Hamm, Rebecca M. Nowak, Cheryl S. Gerardi, Theresa E. Latham, Rong Xu, Amara Luckay, Tracy Chen, Marc Tremblay, Jeffry Shearer, Melissa Wynn, John H. Eldridge, Kelly Warfield, Kevin Spurgers   +14 more
doaj   +1 more source

ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundGPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies.
Heidrun Degen, Oliver Borst, Melanie Ziegler, Ann‐Katrin Mojica Munoz, Janina Jamasbi, Britta Walker, Silvia Göbel, Julia Fassbender, Kristin Adler, Richard Brandl, Götz Münch, Reinhard Lorenz, Wolfgang Siess, Meinrad Gawaz, Martin Ungerer   +14 more
doaj   +1 more source

Interactions of Viral Proteins from Pathogenic and Low or Non-Pathogenic Orthohantaviruses with Human Type I Interferon Signaling

Viruses, 2021
Rodent-borne orthohantaviruses are asymptomatic in their natural reservoir, but they can cause severe diseases in humans. Although an exacerbated immune response relates to hantaviral pathologies, orthohantaviruses have to antagonize the antiviral ...
Giulia Gallo, Grégory Caignard, Karine Badonnel, Guillaume Chevreux, Samuel Terrier, Agnieszka Szemiel, Gleyder Roman-Sosa, Florian Binder, Quan Gu, Ana Da Silva Filipe, Rainer G. Ulrich, Alain Kohl, Damien Vitour, Noël Tordo, Myriam Ermonval   +14 more
doaj   +1 more source

Lectin based glycoprotein analysis [PDF]

, 2008
Many of the biopharmaceutical therapeutics entering the market and currently in clinical trails are recombinant glycoprotein molecules, the glycan moieties of which have a significant impact on efficacy and immunogenicity.
Clarke, Paul A., Goel, Alok, O'Connell, Michael, O'Connor, Brendan, Thompson, Roisin   +4 more
core  

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study. [PDF]

, 2018
BACKGROUND: The recombinant vesicular stomatitis virus (rVSV) vaccine expressing the Zaire Ebola virus (ZEBOV) glycoprotein is efficacious in the weeks following single-dose injection, but duration of immunity is unknown.
ADDO, Marylyn M., Agnandji, Selidji Todagbe, AHMED, Rafi, ANDERSON, Jenna, AUDERSET, Floriane, Bache, Emmanuel Bache, BECKER, Stephan, Bejon, Philip, BORGIANNI, Luisa, Botto, Miriam, Brosnahan, Jessica, CIABATTINI, Annalisa, Combescure, Christophe, DUBEY, Sheri, Engler, Olivier, Fernandes, José F, FERNANDES, José F., GERLINI, Alice, Grillet, Stéphane, HAKS, Marielle C., HARANDI, Ali, HEPPNER, Donald Gray, Huttner, Angela, Kabwende, Lumeka, KIENY, Marie-Paule, KRÄHLING, Verena, Kremsner, Peter, KRISHNA, Sanjeev, Lemaître, Barbara, MEDAGLINI, Donata, Monath, Thomas P, NAKAYA, Helder, Ndungu, Francis Maina, NJUGUNA, Patricia, OROURKE, Fiona, OTTENHOFF, Tom H. M., PAGE, Mark, PEJOSKI, David, Portmann, Jasmine, POZZI, Gianni, POZZI, Gianni, ROTHENBERGER Sylvia, SANTORO, Francesco, Siegrist, Claire-Anne, Siegrist, Denise, Silvera, Peter, VEBCON VSV-EBOVAC, VSV-EBOPLUS Consortia   +47 more
core   +3 more sources

Procalcitonin is a glycoprotein.

Journal of Biological Chemistry, 1981
Messenger RNA extracted from rat medullary carcinoma of the thyroid directs the synthesis in cell-free translation systems of a precursor of calcitonin, Mr = 15,000, substantially larger than the mature form of the hormone, Mr = 3,500. When translations of the mRNA were carried out in the presence of microsomal membranes prepared from a canine pancreas,
N H Bell, Joel F. Habener, John W. Jacobs, P K Lund, John T. Potts   +4 more
openaire   +3 more sources

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

The Diversity of N-Glycans of Chlorella Food Supplements Challenges Current Species Classification

Foods
N-glycans have recently emerged as highly varied elements of Chlorella strains and products. Four years and eighty samples later, the increasing N-glycan diversity calls for a re-examination in the light of concepts of species designations and product ...
Réka Mócsai, Johannes Helm, Karin Polacsek, Johannes Stadlmann, Friedrich Altmann   +4 more
doaj   +1 more source

A Method for Determining the Content of Glycoproteins in Biological Samples

Molecules, 2016
The glycoprotein purified from the mycelium extract of Tremella fuciformis was marked with iodine through the iodine substitution reaction. The content of iodine, which is indicative of the amount of the marked tremella glycoprotein (ITG), was detected ...
Yang Gao, Duoduo Xu, Hongyue Li, Xianling Yang, Mingxing Wang, Qipin Gao   +5 more
doaj   +1 more source