Results 81 to 90 of about 964,671 (415)
Bloch spin waves and emergent structure in protein folding with HIV envelope glycoprotein as an example [PDF]
Phys. Rev. E 93, 032409 (2016), 2015 We inquire how structure emerges during the process of protein folding. For this we scrutinise col- lective many-atom motions during all-atom molecular dynamics simulations. We introduce, develop and employ various topological techniques, in combination with analytic tools that we deduce from the concept of integrable models and structure of discrete ...
arxiv +1 more source
Immobilized fibrinogen activates human platelets through glycoprotein VI
Haematologica, 2018 Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon platelet adhesion to fibrinogen.
P. Mangin +18 more
semanticscholar +1 more source
Effects of HIV and Drugs of Abuse on the Blood-Brain Barrier [PDF]
, 2016 Despite effective systemic therapy, HIV-1 infection within the brain results in neuronal degradation and neurocognitive dysfunction. This neurocognitive dysfunction is worsened in the setting of opiate abuse. The central nervous system (CNS) is protected
Hari, Gopika
core +1 more source
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
Recent Observations on Australian Bat Lyssavirus Tropism and Viral Entry
Viruses, 2014 Australian bat lyssavirus (ABLV) is a recently emerged rhabdovirus of the genus lyssavirus considered endemic in Australian bat populations that causes a neurological disease in people indistinguishable from clinical rabies.
Dawn L. Weir +3 more
doaj +1 more source
The Immune Correlates of Orthohantavirus Vaccine
Vaccines, 2021 Zoonotic transmission of orthohantaviruses from rodent reservoirs to humans has been the cause of severe fatalities. Human infections are reported worldwide, but vaccines have been approved only in China and Korea. Orthohantavirus vaccine development has
Joon-Yong Bae +6 more
doaj +1 more source
Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative [PDF]
Journal of Translational Medicine (2015) 13:124, 2016 Background: In this paper, we present an approach to understand how the basic, clinical and patent knowledge on Ebola is organized and intercommunicated and what leading factor could be shaping the evolution of the knowledge translation process for this disease.
arxiv +1 more source
The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients [PDF]
, 2008 We investigated the relationships between functional genetic variants of the 5-HT(2C) receptor and multidrug-resistant protein (MDR1), coding for P-glycoprotein, and second generation antipsychotic (SDA)-induced weight gain among 108 female schizophrenic
Bilušić, Hrvoje +5 more
core +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4
Frontiers in Microbiology, 2017 Ebola virus (EBOV), a member of the Filoviridae family, causes the most severe form of viral hemorrhagic fever. Although no FDA licensed vaccine or treatment against Ebola virus disease (EVD) is currently available, Ebola virus glycoprotein (GP) is the ...
Chih-Yun Lai +4 more
doaj +1 more source