Results 201 to 210 of about 582,559 (301)

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2. [PDF]

Nature
Vollmer B, Ebel H, Rees R, Nentwig J, Mulvaney T, Schünemann J, Krull J, Topf M, Görlich D, Grünewald K.   +9 more
europepmc   +1 more source

Human Cytomegalovirus Envelope Glycoprotein B [PDF]

, 2020
openaire   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases. [PDF]

J Med Virol
Lestari T, Yawata N, Gonzalez G, Miyadera H, Motooka D, Imamura Y, Oki H, Mori Y, Shirane M, Khor SS, Omae Y, Shimada M, Windy DA, Nakano S, Tsutsui H, Kuramoto S, Fukui C, Nakamura R, Yamana S, Kaburaki T, Mashimo H, Takase H, Yanai R, Hasegawa E, Shibata K, Yawata M, Tokunaga K, Ohguro N, Sonoda KH.   +28 more
europepmc   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition. [PDF]

PLoS Pathog
Xie C, Fang XY, Liu YT, Tian XS, Zhong LY, Wu PH, Zhou H, Li PL, Yang YL, Jiang ZY, Sui SF, Liu Z, Zeng MS, Sun C.   +13 more
europepmc   +1 more source

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion. [PDF]

PLoS Pathog, 2021
Oliver SL, Xing Y, Chen DH, Roh SH, Pintilie GD, Bushnell DA, Sommer MH, Yang E, Carfi A, Chiu W, Arvin AM.   +10 more
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Optimized isolation and purification of native glycoprotein B from herpes simplex virus 1: a streamlined approach. [PDF]

Iran J Microbiol
Yasaghi M, Yamchi A, Tabarraei A, Salari S, Moradi A, Hosseini SD.   +5 more
europepmc   +1 more source