Results 181 to 190 of about 111,765 (333)

On the Relentless Pursuit of an Oral Insulin Delivery System: How Far is Too Far?

Advanced Therapeutics, EarlyView.
Injectable insulin preparations have far outpaced oral ones by virtue of adequate bioavailability and are driven by innovations, including insulin pumps, real‐time blood glucose monitoring, and artificial intelligence. In contrast, oral insulin delivery systems, including nanomedicines, continue to struggle and lag due to varied reasons.
Sourav Bhattacharjee
wiley   +1 more source

Introduction of an ancient founder glycoprotein VI mutation into the Chilean population. [PDF]

Blood Adv, 2022
Dalby A, Mezzano D, Miquel JF, Rivera J, Watson SP, Morgan NV.   +5 more
europepmc   +1 more source

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cγ2 regulation in platelets [PDF]

, 2002
Peter Wonerow, Achim Obergfell, Jonathan I. Wilde, Régis Bobe, Naoki Asazuma, Tomáš Brdička, Albrecht Leo, Burkhart Schraven, Václav Hor̆ejšı́, Sanford J. Shattil, Steve P. Watson   +10 more
openalex   +1 more source

Accelerated Bone Healing via Electrical Stimulation

Advanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun, Wenqing Xie, Yuxiang Wu, Zhou Li, Yusheng Li   +4 more
wiley   +1 more source

Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction

Frontiers in Immunology
IntroductionPlatelets play an important role in cardiovascular diseases. After acute myocardial infarction, platelets display enhanced activation and migrate into the infarct zone.
Friedrich Reusswig, Matthias Dille, E. Krüger, J. Ortscheid, Tobias Feige, S. Gorressen, J.-W. Fischer, Margitta Elvers   +7 more
doaj   +1 more source

Demonstration that a lectin-like receptor (gp90MEL) directly mediates adhesion of lymphocytes to high endothelial venules of lymph nodes. [PDF]

, 1989
Lymphocyte migration from the blood into most secondary lymphoid organs is initiated by a highly selective adhesive interaction with the endothelium of specialized blood vessels known as high endothelial venules (HEV).
Geoffroy, JS, Rosen, SD
core  

Analysis of the Interaction of Platelet Collagen Receptor Glycoprotein VI (GPVI) with Collagen [PDF]

, 2002
Yoshiki Miura, Tsuyoshi Takahashi, Stéphanie Jung, Masaaki Moroi   +3 more
openalex   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Scientific Reports
Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin.
Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +9 more
doaj   +1 more source

FcRγ‐chain signals in the absence of glycoprotein VI [PDF]

Journal of Thrombosis and Haemostasis, 2007
Carl W. Jackson, T. K. Gartner, Jerry Ware, Junling Liu   +3 more
openaire   +3 more sources