Results 321 to 330 of about 111,765 (333)

Implications of glycoprotein VI for theranostics

Thrombosis and Haemostasis, 2014
SummaryGlycoprotein VI (GPVI), a membrane glycoprotein solely expressed in platelets and megakaryocytes, plays a critical role in thrombus formation due to collagen/GPVI-mediated platelet activation and adhesion. Recent studies have shown that surface expression of GPVI on circulating platelets is enhanced in acute cardiovascular diseases such as ...
Gawaz, Meinrad Paul, Vogel, Sebastian, Pfannenberg, Christina, Pichler, Bernd, Langer, Harald, Bigalke, Boris   +5 more
openaire   +4 more sources

Diagnostic and Therapeutic Potentials of Platelet Glycoprotein VI [PDF]

Seminars in Thrombosis and Hemostasis, 2010
Platelets respond immediately to vascular injury by adhesion, aggregation, and thrombus formation. Disruption of the endothelial cell layer exposes extracellular matrix to the bloodstream. Collagen binding to platelet glycoprotein VI (GPVI) mediates the initial adhesion of the rolling platelet to the vascular wound. Signaling by GPVI leads to the onset
Stephan Lindemann, Peter Seizer, Boris Bigalke, Suzanne Fateh-Moghadam, Meinrad Gawaz, Björn F. Krämer   +5 more
openaire   +2 more sources

Platelet Glycoprotein VI

2008
Glycoprotein VI (GPVI) is a membrane glycoprotein unique to platelets and has been identified as a physiological receptor for collagen. Damage to a vessel wall exposes the subendothelial component collagen to platelets in the blood flow. Interaction of platelets with collagen via the receptor GPVI results in platelet activation and adhesion--the ...
Stephanie M. Jung, Masaaki Moroi
openaire   +2 more sources

Dimeric Glycoprotein VI Binds to Collagen but Not to Fibrin

Thrombosis and Haemostasis, 2018
AbstractPlatelet glycoprotein VI (GPVI) acts as a decisive collagen receptor in atherothrombosis. Besides collagen, injured atherosclerotic plaques expose tissue factor (TF) that triggers fibrin formation. Two recent studies reported that platelet GPVI also functions as fibrin receptor, which would importantly widen the mode of action of GPVI-targeted ...
Remco T. A. Megens, Martin Ungerer, Wolfgang Siess, Richard Brandl, Götz Münch, Kristin Adler, Natalie Elia, Mariam Ebrahim, Janina Jamasbi, Reinhard Lorenz, Kerstin Uhland, Yacine M'Bengue, Xavier Blanchet, Christian Weber   +13 more
openaire   +4 more sources

Platelet glycoprotein VI: its structure and function

Thrombosis Research, 2004
Glycoprotein (GP) VI is a platelet membrane protein with a molecular weight of 62 kDa that was identified as a physiological collagen receptor from studies of patients deficient in this protein. GPVI-deficient platelets lacked specifically collagen-induced aggregation and the ability to form thrombi on a collagen surface under flow conditions ...
Stephanie M. Jung, Masaaki Moroi
openaire   +3 more sources

Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis [PDF]

Thrombosis and Haemostasis, 2018
AbstractSepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized.
Adam Corken, Sanjiv Pasala, Jerry Ware, Ahmed Asfari, Ahmed Asfari, Vamsikrishna Kaliki, Parthak Prodhan, Judith A. Dent, Danielle M Herington, Danielle M Herington, Glenda Hefley, Natasha Sra   +11 more
openaire   +2 more sources

Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis

Journal of Medicinal Chemistry, 2020
Pathogenic thrombus formation accounts for the etiology of many serious conditions including myocardial infarction, stroke, deep vein thrombosis, and pulmonary embolism. Despite the development of numerous anticoagulants and antiplatelet agents, the mortality rate associated with these diseases remains high.
Holly Foster, Clare Wilson, Helen Philippou, Richard Foster   +3 more
openaire   +3 more sources

Alboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib

Blood, 2001
Abstract The snake venom C-type lectin alboaggregin A (or 50-kd alboaggregin) from Trimeresurus albolabris was previously shown to be a platelet glycoprotein (GP) Ib agonist. However, investigations of the signal transduction induced in platelets showed patterns of tyrosine phosphorylation that were different from those of other GPIb ...
Beate E. Kehrel, Beate E. Kehrel, Alexei Navdaev, Alexei Navdaev, Dagmar Dörmann, Kenneth J. Clemetson, Kenneth J. Clemetson, Jeannine M. Clemetson, Jeannine M. Clemetson   +8 more
openaire   +3 more sources

Platelet Receptor Expression and Shedding: Glycoprotein Ib-IX-V and Glycoprotein VI

Transfusion Medicine Reviews, 2014
Quantity, quality, and lifespan are 3 important factors in the physiology, pathology, and transfusion of human blood platelets. The aim of this review is to discuss the proteolytic regulation of key platelet-specific receptors, glycoprotein(GP)Ib and GPVI, involved in the function of platelets in hemostasis and thrombosis, and nonimmune or immune ...
Robert K. Andrews, Elizabeth E. Gardiner
openaire   +3 more sources

Platelet Receptor Glycoprotein VI in Ischaemic Stroke

2020
Platelet activation, thrombus growth and subsequent thromboembolism underpins the pathophysiology of ischaemic stroke. At sites of atherothrombotic plaque rupture, it is established that platelet surface receptor glycoprotein (GP) VI-dimer binds to exposed sub-endothelial collagen, initiating the signalling required to cause platelet activation.
openaire   +2 more sources