Results 21 to 30 of about 244,382 (297)

Esophageal Cancer Development: Crucial Clues Arising from the Extracellular Matrix

Cells, 2020
In the last years, the extracellular matrix (ECM) has been reported as playing a relevant role in esophageal cancer (EC) development, with this compartment being related to several aspects of EC genesis and progression.
Antonio Palumbo, Nathalia Meireles Da Costa, Bruno Pontes, Felipe Leite de Oliveira, Matheus Lohan Codeço, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti   +6 more
doaj   +1 more source

Single-dose of a replication-competent adenovirus-vectored vaccine provides sterilizing protection against Rift Valley fever virus challenge

Frontiers in Immunology, 2022
Rift Valley fever virus (RVFV) is one of the most important virulent pathogens causing severe disease in animals and humans. However, there is currently no approved vaccine to prevent RVFV infection in humans. The use of human adenovirus serotype 4 (Ad4)
Ting Bian, Busen Wang, Guangcheng Fu, Meng Hao, Yi Chen, Ting Fang, Shuling Liu, Changming Yu, Jianmin Li, Jianmin Li, Wei Chen   +10 more
doaj   +1 more source

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design

Viruses, 2015
In the 26 years since the discovery of Hepatitis C virus (HCV) a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals.
Alexander W. Tarr, Tanvi Khera, Kathrin Hueging, Julie Sheldon, Eike Steinmann, Thomas Pietschmann, Richard J. P. Brown   +6 more
doaj   +1 more source

Phaseolus vulgaris Erythroagglutinin (PHA-E)-Positive Ceruloplasmin Acts as a Potential Biomarker in Pancreatic Cancer Diagnosis

Cells, 2022
Pancreatic cancer (PC) remains one of the top 10 causes of cancer-related death in recent years. Approximately 80% of PC patients are diagnosed at the middle or advanced stage and miss the opportunity for surgery.
Shanshan Sha, Yating Wang, Menglu Liu, Gang Liu, Ning Fan, Zhi Li, Weijie Dong   +6 more
doaj   +1 more source

Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS

Cell Reports, 2018
Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating blood ...
Tatjana Sajic, Yansheng Liu, Eirini Arvaniti, Silvia Surinova, Evan G. Williams, Ralph Schiess, Ruth Hüttenhain, Atul Sethi, Sheng Pan, Teresa A. Brentnall, Ru Chen, Peter Blattmann, Betty Friedrich, Emma Niméus, Susanne Malander, Aurelius Omlin, Silke Gillessen, Manfred Claassen, Ruedi Aebersold   +18 more
doaj   +1 more source

Recent Advances in Lectin-Based Affinity Sorbents for Protein Glycosylation Studies

Frontiers in Molecular Biosciences, 2021
Glycosylation is one of the most significant post-translational modifications occurring to proteins, since it affects some of their basic properties, such as their half-life or biological activity. The developments in analytical methodologies has greatly
Anastasia Goumenou, Nathalie Delaunay, Valérie Pichon, Valérie Pichon   +3 more
doaj   +1 more source

Potential Plasticity of the Mannoprotein Repertoire Associated to Mycobacterium tuberculosis Virulence Unveiled by Mass Spectrometry-Based Glycoproteomics

Molecules, 2020
To date, Mycobacterium tuberculosis (Mtb) remains the world’s greatest infectious killer. The rise of multidrug-resistant strains stresses the need to identify new therapeutic targets to fight the epidemic.
Laure Tonini, Bashir Sadet, Alexandre Stella, David Bouyssié, Jérôme Nigou, Odile Burlet-Schiltz, Michel Rivière   +6 more
doaj   +1 more source

Potential Alphavirus Inhibitors From Phytocompounds – Molecular Docking and Dynamics Based Approach

Innovative Biosystems and Bioengineering, 2023
Background. Alphaviral diseases are an economic burden all over the world due to their chronicity and distribution worldwide. The glycoproteins E1 and E2 are important for binding to the surface of the host cell by interacting with the receptors and non ...
Maneesha Sharma, Anu Bansal, Shikha Suman, Neeta Raj Sharma   +3 more
doaj   +1 more source

Characterization of the skin mucus in the common octopus Octopus vulgaris (Cuvier) reared paralarvae

European Journal of Histochemistry, 2017
The Octopus vulgaris farming is impaired by the high mortality of the paralarvae during the first month of life. Several factors have been investigated in this regard, but no data exist on the body surface mucus, which represents the interface with the ...
Gianluca Accogli, Giovanni Scillitani, Donatella Mentino, Salvatore Desantis   +3 more
doaj   +1 more source

Carbohydrate composition of rat intestine surface mucus layer after ceftriaxone treatment [PDF]

The Ukrainian Biochemical Journal, 2016
The epidemiological studies have shown that antibiotic treatment increases the susceptibility to inflammatory bowel disease development. The disturbance of mucus layer integrity might be one of the possible mechanisms. The aim of the present study was to
Yu. V. Holota, Ya. A. Olefir, T. V. Dovbynchuk, G. M. Tolstanova   +3 more
doaj   +1 more source