Results 221 to 230 of about 87,090 (247)
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Glycosaminoglycans in Neurofibromas
The Journal of Dermatology, 1990AbstractGlycosaminoglycan (GAG) contents in neurofibromas (NFs) were examined to clarify how well they corresponded to their histological features. Eight cutaneous NFs and three plexiform NFs from five patients with Recklinghausen's (R) disease, two senile NFs, and control dermis were subjected to the isolation of GAGs.
Tetsuo Sasaki, Satoshi Onodera
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Glycosaminoglycans in Urolithiasis
Nephron, 1992To determine if there are differences in urinary glycosaminoglycan (GAG) concentrations, 43 stone-forming patients and 37 healthy control subjects of both sexes were studied. Urinary concentrations of calcium, magnesium, creatinine, uric acid and GAGs were determined.
Alcira Nesse +4 more
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Glycosaminoglycans and Neuroprotection
2011Glycosaminoglycans (GAGs) are basic building blocks of the ground substance of the extracellular matrix and present at the cellular level as an important component of the glycocalyx covering the cell membrane. In addition to the general role of GAGs in maintaining the integrity of the cell and extracellular matrix by retaining water, certain GAGs ...
K. Semeniken, Bertalan Dudas
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New targets for glycosaminoglycans and glycosaminoglycans as novel targets
Expert Review of Proteomics, 2013Biological functions of a variety of proteins are mediated via their interaction with glycosaminoglycans (GAGs). The structural diversity within the wide GAG landscape provides individual interaction sites for a multitude of proteins involved in several pathophysiological processes.
Tiziana Adage +4 more
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Brain glycosaminoglycans and glycosaminoglycan sulphotransferase in sanfilippo syndrome
Clinica Chimica Acta, 1970Analysis of various glycosaminoglycans in brain obtained from two patients with Sanfilippo syndrome indicates that the major glycosaminoglycan accumulated in brain was heparan sulphate. Dermatan sulphate was also increased in one case as compared to normal, whereas only heparan sulphate was present in the other. Chondroitin-4-sulphate sulphotransferase
Bimal K. Bachhawat, Elizabeth George
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Glycosaminoglycans in infectious disease
Biological Reviews, 2013ABSTRACTGlycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens represent the first line of contact between pathogen and host cell and are crucial to a pathogen's invasive potential. Their complexity and structural diversity allow GAGs
Robert J. Linhardt +3 more
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Therapeutic Applications of Glycosaminoglycans
Current Medicinal Chemistry, 2006Complex polysaccharides, hyaluronic acid or hyaluronan (HA), keratan sulfate (KS), chondroitin sulfates (CSs) and heparin (Hep)/heparan sulfate (HS), are a class of ubiquitous molecules exhibiting a wide range of biological functions. They are widely distributed as glycosaminoglycans (GAGs) sidechains of proteoglycans (PGs) in the extracellular matrix ...
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Sulfotransferases in glycosaminoglycan biosynthesis
Current Opinion in Structural Biology, 2003Most of the sulfotransferases participating in glycosaminoglycan biosynthesis have now been identified. Their essential role in generating binding sites for proteins interacting with glycosaminoglycans is apparent. These interactions may influence important biological processes such as growth control, signal transduction, cell adhesion and lipid ...
Marion Kusche-Gullberg, Lena Kjellén
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Glycosaminoglycan microarrays for studying glycosaminoglycan–protein systems
Carbohydrate PolymersMore than 3000 proteins are now known to bind to glycosaminoglycans (GAGs). Yet, GAG-protein systems are rather poorly understood in terms of selectivity of recognition, molecular mechanism of action, and translational promise. High-throughput screening (HTS) technologies are critically needed for studying GAG biology and developing GAG-based ...
John E, Chittum +2 more
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Biomedical Chromatography, 2002
AbstractGlycosaminoglycans are a family of polydisperse, highly sulfated complex mixtures of linear polysaccharides that are involved in many life processes. Defining the structure of glycosaminoglycans is an important factor in elucidating their structure–activity relationship.
Wenjun Mao +2 more
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AbstractGlycosaminoglycans are a family of polydisperse, highly sulfated complex mixtures of linear polysaccharides that are involved in many life processes. Defining the structure of glycosaminoglycans is an important factor in elucidating their structure–activity relationship.
Wenjun Mao +2 more
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