Results 271 to 280 of about 116,862 (285)

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

Investigating the Potential of Curcumin in the Treatment of Nonsmall Cell Lung Cancer: A Systematic Review With Meta‐Analysis, Network Pharmacology, and Mendelian Randomization

Phytotherapy Research, EarlyView.
ABSTRACT To evaluate the efficacy and explore the potential mechanism of curcumin for the treatment and prevention of NSCLC. We searched six databases thoroughly for articles published before December 2024. Stata 15.0 software was applied for systematic review with meta‐analysis.
Yonglu Guo, Haohao Xu, Peng Shen, Ruijun Cai   +3 more
wiley   +1 more source

Facile Decellularization of Stem Cell Spheroids by Integrating Bioactive Nanofibers for Enhanced Wound Healing

Small, EarlyView.
Decellularized stem cell spheroids are limited by inefficient detergent penetration and biomolecule loss. A strategy using polydopamine‐coated nanofibers within hADSC spheroids enables efficient DNA removal while preserving extracellular matrix proteins.
Seung Jae Huh, Yujin Han, Jinkyu Lee, Eunji Park, Se‐Hwan Lee, Jinwoo Na, Su Chin Heo, Heungsoo Shin   +7 more
wiley   +1 more source

Bridging the Gap: How Organ‐on‐a‐Chip Technology Facilitates the Battle against Glioma

Small Science, EarlyView.
This review critically evaluates current state‐of‐the‐art in vitro glioma models especially glioma‐on‐a‐chip models based on readout capability, performance, and physiological relevance. It summarizes the key parameters and proposes a practical framework to guide researchers in selecting the most suitable preclinical models for glioma studies.
Su Liu, Zhenyu Gong, Dairan Zhou, Vanesa Ayala‐Nunez, Tao Xu, Peter Wick   +5 more
wiley   +1 more source

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

Small Science, EarlyView.
This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu, Bobin Mi, Mengfei Liu, Guohui Liu   +7 more
wiley   +1 more source

The Challenges of Vascular Implants: Regulatory Strategies and Biological Responses

Small Science, EarlyView.
Implantable vascular devices are revolutionizing the management of cardiovascular diseases, such as heart failure, by enabling real‐time monitoring and individualized therapy. However, their potential is challenged by regulatory constraints and biological barriers, as device implantation into a vessel can trigger inflammation, thrombosis, and long‐term
Serena Babboni, Rosa Sicari, Lara Russo, Virgilio Mattoli, Giuseppina Basta, Serena Del Turco   +5 more
wiley   +1 more source

HA Self‐Assembled Dual‐Drug‐Loaded Nanoparticles: Integrating Multitargeted Tumor Therapy and Immune Microenvironment Remodeling via Phototherapy and Apoptosis

Small Structures, EarlyView.
The novel anti‐tumor nanoparticle ICG‐HA‐ADH‐CBA‐TATKLA (IHTK) can simultaneously release the fusion peptide TAT‐KLA (TK) and indocyanine green (ICG) in the tumor microenvironment. Specifically, TK can directly activate the mitochondrial apoptosis pathway to induce tumor cell apoptosis; while ICG, under near‐infrared irradiation, enables phototherapy ...
Lixuan Zang, Haomiao Zhu, Bohan Chen, Feng Sun, Jinhua Zhang, Huarong Shao, Yishu Wang, Fei Liu, Haining Tan, Peixue Ling   +9 more
wiley   +1 more source

Unravelling the molecular network structure of biohybrid hydrogels. [PDF]

Mater Today Bio
Sievers-Liebschner J, Dockhorn R, Friedrichs J, Kurth T, Fratzl P, Sommer JU, Werner C, Freudenberg U.   +7 more
europepmc   +1 more source

Fibroblast growth factor-23 remodels vascular extracellular matrix via glycosaminoglycan induction: implications for calcification in chronic kidney disease. [PDF]

Ren Fail
Freise C, Jernej T, Metzkow S, Schnorr J, Taupitz M.   +4 more
europepmc   +1 more source

Potential health benefits of insect bioactive metabolites and consumer attitudes towards edible insects. [PDF]

NPJ Sci Food
Ishara J, Ekaette I, Matendo R, Vandenberg G, Niassy S, Katcho K, Kinyuru J.   +6 more
europepmc   +1 more source