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Glycosaminoglycan microarrays for studying glycosaminoglycan–protein systems
Carbohydrate PolymersMore than 3000 proteins are now known to bind to glycosaminoglycans (GAGs). Yet, GAG-protein systems are rather poorly understood in terms of selectivity of recognition, molecular mechanism of action, and translational promise. High-throughput screening (HTS) technologies are critically needed for studying GAG biology and developing GAG-based ...
John E, Chittum+2 more
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Glycosaminoglycans in lung carcinoma
Human Pathology, 1988In order to better understand the chemical composition of carcinomas of the lung, glycosaminoglycans (GAGs) of lung tumors from 34 patients were studied histochemically and quantitated spectrophotometrically. When the GAG quantity in neoplastic tissue was compared with that in normal lung tissue, total GAG contents in various carcinomas of the lung ...
Minoru Suzuki+2 more
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Serpin–Glycosaminoglycan Interactions
2011Serpins (serine protease inhibitors) have traditionally been grouped together based on structural homology. They share common structural features of primary sequence, but not all serpins require binding to cofactors in order to achieve maximal protease inhibition. In order to obtain physiologically relevant rates of inhibition of target proteases, some
Chantelle M. Rein+2 more
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Glycosaminoglycans and mucopolysaccharidoses
1996Item does not contain ...
Jong, J.G.N. de+4 more
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Glycosaminoglycans in human diabetes.
Diabete & metabolisme, 1983The serum concentrations of different glycosaminoglycan fractions have been studied in diabetic subjects without evidence of vascular complications and compared with those of age-and sex-matched normal subjects. Electrophoretic analysis of the various glycosaminoglycan fractions showed an increase in hyalunoric acid and heparin, and a decrease in ...
CERIELLO A+5 more
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Biosynthesis of Glycosaminoglycans
1979The low levels of glycosaminoglycans present in nervous tissue have in the past deterred the study of their chemistry and metabolism in this tissue. Now, however, the use of radioisotopes, the recent development of sensitive, specific colorimetric and enzyme methodologies, and the development of procedures for the isolation of the various cell types ...
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Cytokines and Glycosaminoglycans (GAGS)
2003Glycosaminoglycans (GAGs), formerly known as mucopolysaccharides, are anionic polysaccharide molecules that are widely distributed among animal tissues and produced by most cell types. Several key immune cytokines have been shown to bind strongly and selectively to these molecules resulting in modulation of their bioactivity and/or tissue distribution.
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