α-Amylase: Its Structure, Molecular Modification, and Application in the Food Field. [PDF]
FoodsLiu G +6 more
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Unlocking the Functional Potential of <i>Lonicera caerulea</i>: Chemical Profile, Antioxidant, and <i>α</i>-Amylase and <i>α</i>-Glucosidase Inhibitory Activities of Extracts from Ripe, Unripe, and Lactofermented Fruits. [PDF]
BiomoleculesKaptsiuh K +4 more
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Enzyme therapy as a promising strategy to overcome multi-drug resistance in pathogens: current advances, key challenges, and future directions. [PDF]
RSC AdvSaini S, Yadav R, Das R, Singh C.
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Mixed-Linkage Cellooligosaccharides: A New Class of Glycoside Hydrolase Inhibitors
ChemBioChem, 2001A new class of inhibitors for beta-D-glycoside hydrolases, in which a single alpha-(1-->4)-glycosidic bond is incorporated into an otherwise all-beta-(1-->4)-linked oligosaccharide, is described. Such mixed beta/alpha-linkage cellooligosaccharides are not transition-state mimics, but instead are capable of utilising binding energy from numerous ...
Fort, S. +5 more
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Strategies for developing carbohydrates as glycoside hydrolase inhibitors
2020The cleavage of the glycosidic bond in glycoconjugates is an important activity in biological systems. The enzymes catalyzing this activity are termed as “glycoside hydrolases” (GH). About 1% of the genome in organisms are encoded by GHs. Researchers have put in tremendous amount of effort in understanding the mechanism of GHs and the effect of their ...
Radhika Thanvi +2 more
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The Synthesis of a New Class of Potential Inhibitors for Glycoside Hydrolases†
Journal of Carbohydrate Chemistry, 2005Some attempts toward the synthesis of novel inhibitors of glycosyl transferases are described. More successfully, the synthesis of an activated cyclopropacyclohexene and an amide and an amine of a cyclopropa‐fused pyranose are described. None of these three novel compounds proved to be a significant inhibitor of a retaining α‐glucosidase from barley. †
Robert Stick, Keith Stubbs
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Mechanism‐Based Inhibitors to Probe Transitional States of Glycoside Hydrolases
2006Recent structural and kinetic studies indicate that glycosidases (glycoside hydrolases) change the peripheral structure of their catalytic sites dynamically to trim glycan structures. Inhibitors that label specific amino acid residues in the active site of these enzymes based on its mechanism of action are powerful tools to probe such a hidden ...
Hiroshi, Hinou +2 more
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While isofagomine and noeuromycin have previously been demonstrated to be effective inhibitors of a range of exo-acting glycosidases, they are usually only very weak inhibitors of endo-glycosidases. However, the disaccharide-like 3- and 4-O-ß-d-glucopyranosylisofagomines have proven to be strong inhibitors of these endo-acting enzymes that utilize ...
Peter J. Meloncelli +6 more
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The Synthesis of Some Epoxyalkyl b- C -Glycosides as Potential Inhibitors of b-Glucan Hydrolases
Australian Journal of Chemistry, 1997The treatment of tetra-O-benzyl-D-glucono-1,5-lactone with various alkenylmagnesium halides gave the intermediate lactols which, upon reduction (Et3SiH/BF3) and protecting group manipulation, yielded alkenyl tetra-O-acetyl-β-D-C-glucopyranosides in good yield.
Best, W.M. +4 more
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The design of covalent inhibitors in glycoscience research is important for the development of chemical biology probes. Here we report the synthesis of a new carbocyclic mechanism-based covalent inhibitor of an α-glucosidase. The enzyme efficiently catalyzes its alkylation via either an allylic cation or a cationic transition state.
Saeideh Shamsi Kazem Abadi +5 more
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