Results 161 to 170 of about 10,058 (190)

Mixed-Linkage Cellooligosaccharides: A New Class of Glycoside Hydrolase Inhibitors

ChemBioChem, 2001
A new class of inhibitors for beta-D-glycoside hydrolases, in which a single alpha-(1-->4)-glycosidic bond is incorporated into an otherwise all-beta-(1-->4)-linked oligosaccharide, is described. Such mixed beta/alpha-linkage cellooligosaccharides are not transition-state mimics, but instead are capable of utilising binding energy from numerous ...
Fort, S., Varrot, A., Schulein, M., Cottaz, S., Driguez, H., Davies, G.J.   +5 more
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Mechanism‐Based Inhibitors to Probe Transitional States of Glycoside Hydrolases

2006
Recent structural and kinetic studies indicate that glycosidases (glycoside hydrolases) change the peripheral structure of their catalytic sites dynamically to trim glycan structures. Inhibitors that label specific amino acid residues in the active site of these enzymes based on its mechanism of action are powerful tools to probe such a hidden ...
Hiroshi, Hinou, Masaki, Kurogochi, Shin-Ichiro, Nishimura   +2 more
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The Synthesis of a New Class of Potential Inhibitors for Glycoside Hydrolases†

Journal of Carbohydrate Chemistry, 2005
Some attempts toward the synthesis of novel inhibitors of glycosyl transferases are described. More successfully, the synthesis of an activated cyclopropacyclohexene and an amide and an amine of a cyclopropa‐fused pyranose are described. None of these three novel compounds proved to be a significant inhibitor of a retaining α‐glucosidase from barley. †
Robert Stick, Keith Stubbs
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Discovery of glycosidated glycyrrhetinic acid derivatives: Natural product-based soluble epoxide hydrolase inhibitors

European Journal of Medicinal Chemistry
There are few reports on soluble epoxide hydrolase (sEH) structure-activity relationship studies using natural product-based scaffolds. In this study, we discovered that C-30 urea derivatives of glycyrrhetinic acid such as 33, rather than C-20/C-3 urea derivatives, possess in vitro sEH inhibitory capabilities.
Qian Liu, Yi-Xin Wang, Zi-Hao Ge, Min-Zhen Zhu, Jing Ding, Hao Wang, Si-Meng Liu, Rui-Chen Liu, Chun Li, Ming-Jia Yu, Yue Feng, Xin-Hong Zhu, Jian-Hua Liang   +12 more
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The Synthesis of Some Epoxyalkyl b-C-Glycosides as Potential Inhibitors of b-Glucan Hydrolases

Australian Journal of Chemistry, 1997
The treatment of tetra-O-benzyl-D-glucono-1,5-lactone with various alkenylmagnesium halides gave the intermediate lactols which, upon reduction (Et3SiH/BF3) and protecting group manipulation, yielded alkenyl tetra-O-acetyl-β-D-C-glucopyranosides in good yield.
Best, W.M., Ferro, V., Harle, J., Stick, R.V., Tilbrook, D.M.G.   +4 more
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Glycoside Hydrolases: Mechanistic Information from Studies with Reversible and Irreversible Inhibitors

1990
Publisher Summary This chapter discusses the results of the studies that permit some generalizations on the catalytic mechanism of glycoside hydrolases from widely differing sources and with different sugar and aglycon specificities and that have become available over the past 15 years.
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D-Glucosylated Derivatives of Isofagomine and Noeuromycin and Their Potential as Inhibitors of β-Glycoside Hydrolases

Australian Journal of Chemistry, 2007
While isofagomine and noeuromycin have previously been demonstrated to be effective inhibitors of a range of exo-acting glycosidases, they are usually only very weak inhibitors of endo-glycosidases. However, the disaccharide-like 3- and 4-O-β-d-glucopyranosylisofagomines have proven to be strong inhibitors of these endo-acting enzymes that utilize ...
Peter J. Meloncelli, Tracey M. Gloster, Victoria A. Money, Chris A. Tarling, Gideon J. Davies, Stephen G. Withers, Robert V. Stick   +6 more
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ChemInform Abstract: Glycoside Hydrolases: Mechanistic Information from Studies with Reversible and Irreversible Inhibitors

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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ChemInform Abstract: The Synthesis of Some Epoxyalkyl β‐C‐Glycosides as Potential Inhibitors of β‐Glucan Hydrolases.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
W. M. BEST, V. FERRO, J. HARLE, R. V. STICK, D. M. G. TILBROOK   +4 more
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ChemInform Abstract: Cyclic Guanidinium Ions as Analogues of Glycosyl Cations are Competitive and Noncompetitive Inhibitors of Glycoside Hydrolases.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. LEHMANN, B. ROB
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