Results 121 to 130 of about 151,596 (239)

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili   +16 more
wiley   +1 more source

Rutin Stabilises β‐Catenin Through GSK3β Inhibition to Promote Hair Follicle Regeneration

open access: yesCell Proliferation, EarlyView.
Rutin directly binds to GSK3β, stabilising β‐catenin and activating Wnt/β‐catenin signalling to drive hair cycle.
Yanyan Zhang   +10 more
wiley   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

open access: yesThe FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola   +11 more
wiley   +1 more source

Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome

open access: yesThe FEBS Journal, EarlyView.
Ulvan is a polysaccharide available from green seaweed with beneficial properties for various applications. The full potential of ulvan requires enzymatic degradation of the polymer, thus producing ulvan oligosaccharides. This study expands the armoury of characterised ulvan lyases.
Andrius Jasilionis   +8 more
wiley   +1 more source

The Cardioactive Glycosides [PDF]

open access: yesJournal of Pharmacy and Pharmacology, 1949
Arthur Stoll, Rer Nat, Med Pharm
openaire   +2 more sources

Reinventing henna: Enzyme‐catalysed colour release from stabilized Lawsonia inermis L. extracts

open access: yesInternational Journal of Cosmetic Science, EarlyView.
The instability and reduced dyeing performance of a cosmetic formulation containing 2‐hydroxy‐1,4‐naphthoquinone (lawsone), derived from Lawsonia inermis L., is demonstrated in comparison to a novel two‐component system. This system comprises one formulation with naturally occurring lawsone precursors and a second containing a specific hydrolase ...
Nele Dallmann   +2 more
wiley   +1 more source

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