Results 141 to 150 of about 14,058 (187)

Glycosphingolipids and cell death

Glycoconjugate Journal, 2003
Sphingolipids have been implicated in various cellular processes including growth, cell-cell or ligand-receptor interactions, and differentiation. In addition to their importance as reservoirs of metabolites with important signaling properties, sphingolipids also help provide structural order to plasma membrane lipids and proteins within the bilayer ...
Meryem, Bektas, Sarah, Spiegel
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Glycosphingolipids and Insulin Resistance

2011
Glycosphingolipids are structural membrane components, residing largely in the plasma membrane with their sugar-moieties exposed at the cell's surface. In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. A chronic state of insulin resistance is a rapidly increasing disease condition in Western and developing ...
Aerts, J.M., Boot, R.G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F.M., Dekker, N., Groen, A.K., Ottenhof, M., Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H.S.   +15 more
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The Degradation of Glycosphingolipids by Air

Journal of Biochemistry, 1997
Exposure of glycosphingolipids to air irreversibly destroys the integrity of these lipids within a few hours. It was established that among the natural constituents of air, ozone, at commonly observed daytime levels, is responsible for the observed degradation.
R, Jennemann, B L, Bauer, H, Wiegandt
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Soluble Adamantyl Glycosphingolipid Analogs as Probes of Glycosphingolipid Function

2006
Despite the extensive structural characterization of glycosphingolipids (GSLs), their functions in cell physiology and pathobiology remain elusive. This is largely owing to the fact that they are difficult to handle, being insoluble in aqueous media, and that no one gene alone determines their synthesis. The heterogeneity of the lipid moiety provides a
Clifford, Lingwood, Skanda, Sadacharan, Maan, Abul-Milh, Murugespillai, Mylvaganum, Marcus, Peter   +4 more
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Topology of glycosphingolipid degradation

Trends in Cell Biology, 1996
Glycosphingolipids (GSLs) form cell-type-specific patterns on the surface of eukaryotic cells. Degradation of plasma-membrane-derived GSLs in the lysosomes after internalization through the endocytic pathway is achieved through the concerted actions of hydrolysing enzymes and sphingolipid activator proteins.
K, Sandhoff, T, Kolter
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Glycosphingolipids in membrane architecture

Journal of Supramolecular Structure, 1977
AbstractAs part of a program to investigate the behavior and interactions of glycolipids in biological membranes we have synthesized spin‐labeled derivatives of 2 families of carbohydrate‐bearing ceramides (glycosphingolipids): simple neutral glycolipids and gangliosides.
F J, Sharom, C W, Grant
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Glycosphingolipids of human plasma

Archives of Biochemistry and Biophysics, 1985
A number of glycosphingolipids, including 10 gangliosides, not previously identified in human plasma have been characterized. The plasma contains 2 micrograms of lipid-bound sialic acid/ml plasma and 54% of the gangliosides are monosialo, 30% disialo, 10% trisialo, and 6% tetrasialo.
S K, Kundu, I, Diego, S, Osovitz, D M, Marcus   +3 more
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Glycosphingolipids as toxin receptors

Seminars in Cell & Developmental Biology, 2004
A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis.
Daniel C, Smith, J Michael, Lord, Lynne M, Roberts, Ludger, Johannes   +3 more
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Molecular arrangements in glycosphingolipids

Chemistry and Physics of Lipids, 1972
Abstract A number of homogeneous glycosphingolipids have been prepared and their structural behaviour studied in the solid state as well as in lipid-water systems and in surface films. Mainly X-ray diffraction techniques have been used in the phase analyses. A very complex phase pattern is usually found — e.g.
Sixten Abrahamsson, Irmin Pascher, Kåre Larsson, Karl-Anders Karlsson   +3 more
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Glycosphingolipids and Kidney Disease

2011
Glycosphingolipids, derived from the addition of sugar-moieties to the sphingolipid ceramide, are highly abundant in the kidney. Glycosphingolipids are known to play an important role in organ function at least in part from inherited lipid storage diseases such as Anderson-Fabry disease (Fabry's disease; FD) that results from a mutation in alpha ...
Andrew R, Mather, Leah J, Siskind
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