Results 101 to 110 of about 175,061 (321)

Comparative genomic analysis of the human gut microbiome reveals a broad distribution of metabolic pathways for the degradation of host-synthetized mucin glycans [PDF]

arXiv, 2017
The colonic mucus layer is a dynamic and complex structure formed by secreted and transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins. Colonic mucus consists of a loose outer layer and a dense epithelium-attached layer. The outer layer is inhabited by various representatives of the human gut microbiota (HGM). Glycans
arxiv  

Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022
Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen, Isaac Kyei, Arden Hatch, David S. Hage   +3 more
wiley   +1 more source

Protein Glycosylation in Aspergillus fumigatus Is Essential for Cell Wall Synthesis and Serves as a Promising Model of Multicellular Eukaryotic Development

International Journal of Microbiology, 2012
Glycosylation is a conserved posttranslational modification that is found in all eukaryotes, which helps generate proteins with multiple functions. Our knowledge of glycosylation mainly comes from the investigation of the yeast Saccharomyces cerevisiae ...
Cheng Jin
doaj   +1 more source

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

mSphere, 2019
O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-GalNAc-(1,3)-β-GalNAc to membrane exported proteins in Burkholderia cenocepacia is required for bacterial fitness and ...
Cameron C. Oppy, Leila Jebeli, Miku Kuba, Clare V. Oates, Richard Strugnell, Laura E. Edgington-Mitchell, Miguel A. Valvano, Elizabeth L. Hartland, Hayley J. Newton, Nichollas E. Scott   +9 more
doaj   +1 more source

Efficient and minimal length parametric conformal prediction regions [PDF]

arXiv, 2019
Conformal prediction methods construct prediction regions for iid data that are valid in finite samples. We provide two parametric conformal prediction regions that are applicable for a wide class of continuous statistical models. This class of statistical models includes generalized linear models (GLMs) with continuous outcomes.
arxiv  

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Accepted Article.
Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe Bornscheuer   +4 more
wiley   +1 more source

Recognition of glycine versus non‐glycine citrulline motifs dictates the HLA class II association of anti‐citrullinated protein antibodies ‐ insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) associated anti‐citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline‐amino acid motifs, resulting in heterogeneous ACPA‐profiles among patients. Here we analyzed ACPA‐patterns by recognized citrulline‐motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE ...
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Tue Wenzel Kragstrup, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Johan Askling, Caroline Grönwall   +31 more
wiley   +1 more source

Enzymolysis and glycosylation synergistic modified ovalbumin: functional and structural characteristics

International Journal of Food Properties, 2018
The functional and structural properties of enzymatic hydrolysis and glycosylation synergistic modified ovalbumin (OVA) were investigated. The results showed that hydrolysis and glycosylation had synergetic effects on emulsifying and foaming properties ...
Lili Liu, Yu Li, Sangeeta Prakash, Xiaoning Dai, Yuanyuan Meng   +4 more
doaj   +1 more source

Quasi-Steady-State Approach for Efficient Multiscale Simulation and Optimization of mAb Glycosylation in CHO Cell Culture [PDF]

arXiv
Glycosylation is a critical quality attribute for monoclonal antibody (mAb) production, influenced by both process conditions and cellular mechanisms. Multiscale mechanistic models, spanning from the bioreactor to the Golgi apparatus, have been proposed for analyzing the glycosylation process.
arxiv  

m6A‐mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly

Autism Research, EarlyView.
ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD‐DM) seen at three years of age is associated with co‐occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD‐DM have yet to be delineated. In this study, we identified additional ASD‐DM candidate genes
Sierra S. Nishizaki, Nicholas K. Haghani, Gabriana N. La, Natasha Ann F. Mariano, José M. Uribe‐Salazar, Gulhan Kaya, Melissa Regester, Derek Sayre Andrews, Christine Wu Nordahl, David G. Amaral, Megan Y. Dennis   +10 more
wiley   +1 more source