Results 161 to 170 of about 175,061 (321)

In-situ profiling of glycosylation on single cells with surface plasmon resonance imaging

Nature Communications
Cellular glycosylation is crucial for cell recognition, signal transduction, and the development of various diseases, especially in tumor initiation, progression, and metastasis.
Xiaoyin Liu, Jinbiao Ma, Yunrui Zhang, Yi Xu, Yunxiao Wang, Dehong Yang, Di Wang, Qingjun Liu, Fenni Zhang   +8 more
doaj   +1 more source

Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation.

, 1979
H. Franklin Bunn, Robert Shapiro, Michael McManus, L.M. Garrick, M.J. McDonald, Paul M. Gallop, Kenneth H. Gabbay   +6 more
openalex   +1 more source

Total Synthesis of Kanamycins

Chemistry – A European Journal, Accepted Article.
Structurally‐modified aminoglycosides, such as kanamycin, have shown promise as antibiotics and premature termination codon read‐through drugs to fight against drug‐resistant bacteria and to treat genetic diseases, respectively. Therefore, research on developing and discovering aminoglycoside antibiotics has recently increased.
Kanae Hosomi, Banjo Imai, Naoto Takemura, Kazuki Senoo, Chigusa Hayashi, Masayuki Igarashi, Kazunobu Toshima, Daisuke Takahashi   +7 more
wiley   +1 more source

Complete localization of the intrachain disulphide bonds and the N-glycosylation points in the α-subunit of human platelet glycoprotein IIb [PDF]

, 1989
Juan J. Calvete, Agnes Henschen, José González-Rodrı́guez   +2 more
openalex   +1 more source

Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides

Chemistry – A European Journal, Accepted Article.
The search for safer and more effective vaccine adjuvants has intensified in recent years, with triterpenoid saponins like QS‐21 and its analogues emerging as promising candidates. We report the synthesis of a novel QS‐21 analogue featuring betulinic acid as aglycone, a lupane‐type triterpenoid with low toxicity derived from white birch bark.
Oscar Javier Gamboa Marin, Yasmine Adda-Bouchard, Balla Sylla, Nitish Verma, Tania Charpentier, Maya Huber, Guillaume Lopez, André Pichette, Alain Lamarre, Charles Gauthier   +9 more
wiley   +1 more source

High-throughput antibody screening with high-quality factor nanophotonics and bioprinting [PDF]

arXiv
Empirical investigation of the quintillion-scale, functionally diverse antibody repertoires that can be generated synthetically or naturally is critical for identifying potential biotherapeutic leads, yet remains burdensome. We present high-throughput nanophotonics- and bioprinter-enabled screening (HT-NaBS), a multiplexed assay for large-scale, sample-
arxiv  

The ABC of glycosylation [PDF]

Nature Reviews Cancer, 2010
Giovanni Luca Beretta, Laura Gatti, Paola Perego   +2 more
openaire   +3 more sources

GDF15 Analogues Acting as GFRAL Ligands

ChemMedChem, EarlyView.
Considering the great importance of the GDF15/GRAL/RET signalling pathway, this review focuses on GDF15‐derived analogues able to act either as GFRAL agonists or antagonists, investigating their possible pharmacological applications in the treatment of GDF15‐related conditions, such as obesity and diabetes (agonist), or cancer‐induced nausea and ...
Andrea Di Santo, Livio Tarchi, Gianluca Villa, Giovanni Castellini, Valdo Ricca, Roberta Squecco, Anna Maria Papini, Feliciana Real‐Fernandez, Paolo Rovero   +8 more
wiley   +1 more source

Glycosylation [PDF]

, 2008
openaire   +1 more source

Improved C5‐amide bioisosteres for human neuraminidase 1 inhibitors based on 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid (DANA)

ChemMedChem, Accepted Article.
Neuraminidase enzymes (NEU) play a crucial role in many physiological and pathological conditions. Humans have four isoenzymes of NEU and their specific roles continue to be investigated. Isoenzyme‐selective inhibitors are needed as research tools and may lead to future therapeutics.
Mostafa Radwan, Elisa Garcia Carvajal, Christopher W Cairo   +2 more
wiley   +1 more source