Results 191 to 200 of about 406,798 (331)
Transcriptomics as a predictor of biopharmaceutically favourable glycan profiles
Frontiers in Cell and Developmental BiologyN-glycosylation plays a crucial role in defining the pharmacological properties and efficacy of therapeutic proteins, commonly referred to as biologics. The inherent complexity and lack of a templated process in glycosylation leads to a wide variation in
Ben West +7 more
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Altered glycosylation in cancer: A promising target for biomarkers and therapeutics.
Biochimica et biophysica acta. Reviews on cancer, 2020 D. Thomas +2 more
semanticscholar +1 more source
Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease
Annals of Neurology, EarlyView.Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias +23 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Silver nanoparticles (AgNPs) synthesized using eco‐friendly green synthesis approaches exhibit remarkable antimicrobial activity and enhanced drug delivery potential. Polymer‐AgNPs conjugates further improve drug stability and targeted delivery, offering a multifunctional platform for biomedical applications.
Mukil Madhusudanan +6 more
wiley +1 more source
Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation.
, 1979 H. Franklin Bunn +6 more
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Exploitation of glycosylation in enveloped virus pathobiology
Biochimica et Biophysica Acta, 2019 Yasunori Watanabe +3 more
semanticscholar +1 more source
Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, EarlyView.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source
The role of glycosylation on the biosynthesis, degradation, and secretion of the acth‐β‐lipotropin common precursor and its peptide products [PDF]
, 1978 Y. Peng Loh, Harold Gainer
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Impact of Glycoclustering on Stiffening of MUC5AC Peptides Revealed by High‐Efficiency Synthesis
Angewandte Chemie, EarlyView.Peptides featuring a previously unattained degree of glycoclustering were obtained by fully automated solid‐phase synthesis in 1,3‐dioxolane/Tween‐20 and diselenide–selenoester ligation. Circular Dichroism (CD) and Pulsed Electron‐Electron Double Resonance (PELDOR) measurements of densely GalNAcylated MUC5AC multi‐tandem repeat peptides provided ...
Arseniy Galashov +9 more
wiley +1 more source