Results 191 to 200 of about 191,408 (290)

Dynamic pH profiles drive higher cell‐specific and volumetric productivity

Biotechnology Progress, EarlyView.
Implementation of dyamic pH profiles for increased CHO cell culture productivity. Abstract Mammalian cell cultures in bioreactors rely heavily on critical process parameter control to ensure optimal growth, productivity, and reproducibility to produce recombinant therapeutic proteins. Culture pH has been shown to be a critical parameter that influences
Stephanie R. Klaubert, Dylan G. Chitwood, Danqia Peng, Erin Redman, Ji Young L. Anderson, Nicholas R. Sandoval, Sarah W. Harcum   +6 more
wiley   +1 more source

Bioinformatic analysis of glycosylation-related genes in intervertebral disc degeneration and their roles in immune infiltration and diagnostic models. [PDF]

Sci Rep
Liu G, Qin Q, Zhong W, Liu H, Xie Y, Huang X, Liu G, Li Y.   +7 more
europepmc   +1 more source

Artificial intelligence and machine learning‐assisted digital applications for biopharmaceutical manufacturing

Biotechnology Progress, EarlyView.
Abstract Artificial intelligence and automation are no longer just buzzwords in the biopharmaceutical industry. The manufacturing of a class of biologics, comprising monoclonal antibodies, cell therapies, and gene therapies, is far more complex than that of traditional small molecule drugs.
Shyam Panjwani, Hao Wei, John Mason
wiley   +1 more source

Identification of Compound Heterozygous <i>DPM1</i> Variants in a Pediatric Patient With Congenital Disorder of Glycosylation Type Ie. [PDF]

Case Rep Pediatr
Song W, Zhou W, Yang L, Tang L.
europepmc   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

Biotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya, Rajesh K. Mistry, Susie Sou, Sonja Hess, Bijay Khanal, Zayla Schaeffer, Jie Zhu, Lina Chakrabarti   +7 more
wiley   +1 more source

Yin Yang 1 Promotes Antiprogrammed Cell Death-1 Resistance in Hepatocellular Carcinoma through Polypeptide N-Acetylgalactosaminyltransferase 16-Mediated Glycosylation of Programmed Death Ligand-1. [PDF]

MedComm (2020)
Lin SS, Xiao G, Liu QQ, Xue JH, Chen ZJ, Zhang HH, Zhu XP, Huang KL, Yang CN, Zhu K, Lin HM, Zhang R.   +11 more
europepmc   +1 more source

From Molecule to Meaning: Click and Bioorthogonal Chemical Reporters for Plant Systems, Biological Imaging, and Artistic Expression

ChemBioChem, EarlyView.
At the intersection of chemical biology, plant imaging, and contemporary art, this review introduces the concept of chembioart. By tracing how chemical reporters illuminate plant biomolecules in vivo, their role not only in advancing scientific understanding but also in inspiring transdisciplinary collaborations and visual expression is highlighted ...
Marie Hinnebo, Clémence Simon, Adèle Tilouine, Corentin Spriet, Christophe Biot   +4 more
wiley   +1 more source

Temporal dynamics of IgG-mediated immunometabolic dysfunction: from acute obesity to chronic aging. [PDF]

Front Immunol
Kim S, Kim J, Lee HL, Kim MS.
europepmc   +1 more source

The Significance of Glycosylation Analysis in Development of Biopharmaceuticals

, 2009
Nana Kawasaki, Satsuki Itoh, Noritaka Hashii, Daisuke Takakura, Qin Yan, Xiaoyu Huang, Teruhide Yamaguchi   +6 more
openalex   +2 more sources

From glycosylation to glycosylation diseases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
Jaeken, Jaak, Matthijs, Gert
openaire   +1 more source