Results 191 to 200 of about 216,514 (309)

Acute vascular redox modulation by SGLT2 inhibition in non-diabetic patients. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Lukenda KC, Gasparovic AC, Milic M, Radovani B, Vuckovic F, Jakab J, Vucic D, Kovacevic A, Gudelj I.   +8 more
europepmc   +1 more source

Multivariate phase‐dependent optimization of bioprocesses boosts performance and quality—Why timing (of exposure) matters

Biotechnology Progress, EarlyView.
Abstract Applying a single parameter set to describe complex mammalian kinetics often is too simplistic, as it fails to capture sensitive cell‐to‐environment interactions that may be exploited to optimize production performance. To resolve this time dependency, intra‐experimental parameter shifts as part of design of dynamic experiments (DoDE) can be ...
Samuel Kienzle, Lisa Junghans, Anja Wittmann, Stefan Wieschalka, Ralf Takors, Nicole Erika Radde, Beate Presser, Verena Nold   +7 more
wiley   +1 more source

Structural and functional characterization of human kallistatin. [PDF]

Biochem Biophys Rep
Pham STD, Nielsen KW, Graversen JH, Kristensen N, Steffensen LB, Lundgaard AR, Martín-Ventura JL, Højrup P, Palarasah Y.   +8 more
europepmc   +1 more source

β‐1,4‐galactosyltransferase 1 inhibitors modulate cellular N‐glycan profiles

Biotechnology Progress, EarlyView.
Graphical representation of the study workflow used to investigate the effects of known in vitro galactosyltransferase inhibitors on cell culture performance and recombinant IgG galactosylation. Abstract N‐glycosylation is a key post‐translational modification of proteins influencing their physicochemical properties as well as biological activity. This
Jaka Kranjc, Stane Pajk, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +4 more
wiley   +1 more source

Enzymatic 1,4-addition of 2-hydroxy-3-keto-glucal for β-selective aryl-<i>C</i>-glycosylation of polyphenols.

Chem Commun (Camb)
Kastner K, Pfeiffer M, Nidetzky B.
europepmc   +1 more source

Hypoxia-Enhanced N110 Glycosylation of Hemagglutinin Promotes H3N2 Influenza Virus Fitness by Modulating Receptor Binding and Immune Evasion. [PDF]

Viruses
Zhang T, Fang Y, Liu J, Guo A, Yuan B, Zhang Y, Ding L, Ye Q.   +7 more
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Catalyst-Controlled Chemoselective β-Mannosylation of Phenols Via Attractive Noncovalent Interactions. [PDF]

J Am Chem Soc
Bikovtseva AA, Nielsen MM, Jacobsen EN.
europepmc   +1 more source

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, EarlyView.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

The revised three-step detour pathway in dolichol biosynthesis is evolutionarily conserved in budding yeast. [PDF]

Proc Natl Acad Sci U S A
Hanaoka K, Matsunaga K, Shimizu S, Sakai S, Pichler H, Funato K.   +5 more
europepmc   +1 more source