Results 71 to 80 of about 175,061 (321)
Carbohydrates and glycosylation [PDF]
WormBook, 2006 The C. elegans genome contains sequences similar to a large number of mammalian genes implicated in the assembly, processing, and modification of glycans. In recent years, spectacular progress has been made in developing and refining tools to obtain structural information with small amounts of material, increasing our understanding of glycan structural
openaire +3 more sources
Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles
Advanced Science, EarlyView.Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon +25 more
wiley +1 more source
Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion
Advanced Science, EarlyView.Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.This study designs an anchor peptide‐based immobilization strategy to expand the application of Pickering emulsion to glycosyltransferases (GTs) for the first time, addressing low conversion challenge in aqueous solutions. The glycosylation Pickering emulsion achieved more than 90% conversion of natural product glycosides with high recyclability ...
Peng Zhang +5 more
wiley +2 more sources
Current Research in Pharmacology and Drug Discovery, 2022 Dysregulated surface glycoproteins play an important role in tumor cell proliferation and progression. Abnormal glycosylation of these glycoproteins may activate tumor signal transduction and lead to tumor development.
Ziyuan Gao +6 more
doaj
Advanced Science, EarlyView.The study highlights the potential of recombinant galaxin (a coral protein) as a novel and effective biomaterial for bone regeneration. It binds to ATP synthase subunit β (ATP5B) in mouse pre‐osteoblasts, thereby causing increased ATP production and mitochondrial activity.
Fei Yu +6 more
wiley +1 more source
Variation of the serum N‐glycosylation during the pregnancy of a MPI‐CDG patient
JIMD Reports, 2021 For the first time the glycosylation of a patient with a MPI‐CDG during pregnancy is monitored. MPI‐CDG, is characterised by a deficiency in mannose‐6‐phosphate isomerase (MPI) leading to a reduced pool of glycosylation precursors, impairing the ...
Elodie Lebredonchel +4 more
doaj +1 more source
Folding of Pig Gastric Mucin Non-glycosylated Domains: A Discrete Molecular Dynamics Study [PDF]
arXiv, 2009 Mucin glycoprotein consist of tandem repeating glycosylated regions flanked by non-repetitive protein domains with little glycosylation. These non-repetitive domains are involved in the pH dependent gelation of gastric mucin, which is essential to protecting the stomach from autodigestion.
arxiv
Accelerating Bayesian inference of dependency between complex biological traits [PDF]
arXiv, 2022 Inferring dependencies between complex biological traits while accounting for evolutionary relationships between specimens is of great scientific interest yet remains infeasible when trait and specimen counts grow large. The state-of-the-art approach uses a phylogenetic multivariate probit model to accommodate binary and continuous traits via a latent ...
arxiv