Results 71 to 80 of about 406,798 (331)

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Science Advances, 2020
Variation in key transcription factors and glycogenes modifies IgG glycosylation and has an influence on inflammatory diseases. Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of ...
L. Klarić, Y. Tsepilov, Chloe M. Stanton, M. Mangino, Timo Tõnis Sikka, T. Esko, E. Pakhomov, P. Salo, J. Deelen, S. McGurnaghan, Toma Keser, F. Vučković, I. Ugrina, Jasminka Krištić, I. Gudelj, J. Štambuk, R. Plomp, M. Pučić-Baković, Tamara Pavić, Marija Vilaj, I. Trbojević-Akmačić, Camilla Drake, P. Dobrinić, J. Mlinarec, B. Jelušić, Anne Richmond, M. Timofeeva, A. Grishchenko, Julia Dmitrieva, M. Bermingham, S. Sharapov, S. Farrington, E. Theodoratou, H. Uh, M. Beekman, E. Slagboom, E. Louis, M. Georges, M. Wuhrer, H. Colhoun, M. Dunlop, M. Perola, K. Fischer, O. Polašek, H. Campbell, I. Rudan, James F. Wilson, V. Zoldoš, V. Vitart, T. Spector, Y. Aulchenko, G. Lauc, C. Hayward   +52 more
semanticscholar   +1 more source

Glycosylation site alteration in the evolution of influenza A (H1N1) viruses. [PDF]

PLoS ONE, 2011
Influenza virus typically alters protein glycosylation in order to escape immune pressure from hosts and hence to facilitate survival in different host environments.
Shisheng Sun, Qinzhe Wang, Fei Zhao, Wentian Chen, Zheng Li   +4 more
doaj   +1 more source

Advances in Bacterial Oligosaccharyltransferase Structure Elucidation and Potential Application to Glycoconjugate Vaccine Design

Frontiers in Bioscience-Landmark, 2023
Glycosylation is one of the most common post-translational modifications of proteins across all kingdoms of life. Diverse monosaccharides and polysaccharides can be attached to a range of amino acid residues generating N-glycosylation, O-glycosylation, C-
Riye Lu, Pengwei Li, Li Zhu, Ming Xian Chang, Songying Ouyang   +4 more
doaj   +1 more source

Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens [PDF]

, 2010
Presently some three hundred post-translational modifications are known to occur in bacteria in vivo. Many of these modifications play critical roles in the regulation of proteins and control key biological processes.
Graham, Robert L. J., Hess, Sonja
core   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]

, 2012
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M., Driggers, Edward M., Goddard, William A., III, Hill, Collin, Hsieh-Wilson, Linda C., Keenan, Marie C., Mason, Daniel E., Peters, Eric C., Yi, Wen   +8 more
core   +2 more sources

Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases

Glycobiology, 2020
Abundant evidence points to a critical role for antibodies in protection and pathology across infectious diseases. While the antibody variable domain facilitates antibody binding and the blockade of infection, the constant domain (Fc) mediates cross talk
Edward B. Irvine, G. Alter
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

DC-SIGN Binding Contributed by an Extra N-Linked Glycosylation on Japanese Encephalitis Virus Envelope Protein Reduces the Ability of Viral Brain Invasion

Frontiers in Cellular and Infection Microbiology, 2018
The major structural envelope (E) protein of Japanese encephalitis virus (JEV) facilitates cellular binding/entry and is the primary target of neutralizing antibodies.
Jian-Jong Liang, Min-Wei Chou, Yi-Ling Lin, Yi-Ling Lin   +3 more
doaj   +1 more source

Discovery of Serotransferrin Glycoforms: Novel Markers for Diagnosis of Liver Periductal Fibrosis and Prediction of Cholangiocarcinoma. [PDF]

, 2019
Cholangiocarcinoma (CCA) caused by chronic liver fluke infection is a major public health problem in Northeast Thailand. Identification of CCA risk groups is urgently needed for the control of CCA in this region.
Barboza, Mariana, Chamadol, Nittaya, Jamnongkan, Wassana, Khuntikeo, Narong, Lebrilla, Carlito B, Loilome, Watcharin, Pairojkul, Chawalit, Sithithaworn, Paiboon, Techasen, Anchalee, Thanan, Raynoo, Yongvanit, Puangrat   +10 more
core   +2 more sources