Results 121 to 130 of about 126,630 (231)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

open access: yesAngewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Glycosyltransferases

open access: yesJournal of Biological Chemistry, 1989
J C Paulson, K J Colley
openaire   +1 more source

Disruption of Asparagine Synthetase Is Associated to Increased Biomass in Lotus japonicus

open access: yesPlant Biotechnology Journal, Volume 24, Issue 7, Page 4471-4483, July 2026.
ABSTRACT Asparagine (Asn) constitutes the major form of nitrogen translocated within Lotus japonicus plants. In this work we use knock‐out (KO) LORE1 mutants‐deficient in the asparagine synthetase gene (LjASN1), which is the most highly expressed ASN gene in plants grown under non‐symbiotic (NS) conditions, but much less expressed under symbiotic (S ...
Sara Rosa‐Téllez   +5 more
wiley   +1 more source

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

open access: yesPlant Biotechnology Journal, Volume 24, Issue 7, Page 4528-4545, July 2026.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song   +14 more
wiley   +1 more source

Tuning Xylan Polymerisation Enhanced Fibre Digestibility Without Biomass Loss in Sheepgrass (Leymus chinensis)

open access: yesPlant Biotechnology Journal, Volume 24, Issue 7, Page 4484-4486, July 2026.
ABSTRACT Leymus chinensis (sheepgrass), a dominant perennial grass of the Eurasian Steppe, is a crucial source of carbohydrates and energy for ruminants. However, the lignocellulose recalcitrance severely limits its digestibility. Here, we targeted xylan, a major hemicellulose interacting with cellulose and lignin in cell wall. To improve digestibility,
Mengjie Zhao   +18 more
wiley   +1 more source

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

open access: yesPlant, Cell &Environment, Volume 49, Issue 7, Page 3500-3517, July 2026.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse   +6 more
wiley   +1 more source

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