Results 41 to 50 of about 136,588 (299)

Elucidating the multifaceted role of MGAT1 in hepatocellular carcinoma: integrative single-cell and spatial transcriptomics reveal novel therapeutic insights

Frontiers in Immunology
BackgroundGlycosyltransferase-associated genes play a crucial role in hepatocellular carcinoma (HCC) pathogenesis. This study investigates their impact on the tumor microenvironment and molecular mechanisms, offering insights into innovative ...
Yang Li, Yuan Chen, Yuan Chen, Danqiong Wang, Ling Wu, Tao Li, Na An, Haikun Yang   +7 more
doaj   +1 more source

Crystal Structure of a Virus-Encoded Putative Glycosyltransferase [PDF]

, 2010
The chloroviruses (family Phycodnaviridae), unlike most viruses, encode some, if not most, of the enzymes involved in the glycosylation of their structural proteins.
Ying Zhang, Gentry L. Lewis, Baxa, Ulrich, Rossmann, Michael G., Lewis, Gentry L., Ulrich Baxa, Ye Xiang, Zhang, Ying, Steven, Alasdair C., James L. Van Etten, Alasdair C. Steven, Van Etten, James L., Xiang, Yi, Michael G. Rossmann   +13 more
core   +1 more source

Processivity in Bacterial Glycosyltransferases [PDF]

ACS Chemical Biology, 2019
Extracellular polysaccharides and glycoproteins of pathogenic bacteria assist in adherence, autoaggregation, biofilm formation, and host immune system evasion. As a result, considerable research in the field of glycobiology is dedicated to study the composition and function of glycans associated with virulence, as well as the enzymes involved in their ...
Liubov Yakovlieva, Marthe T. C. Walvoort
openaire   +3 more sources

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Glycosyltransferase-related long non-coding RNA signature predicts the prognosis of colon adenocarcinoma

Frontiers in Oncology, 2022
PurposeColon adenocarcinoma (COAD) is the most common type of colorectal cancer (CRC) and is associated with poor prognosis. Emerging evidence has demonstrated that glycosylation by long noncoding RNAs (lncRNAs) was associated with COAD progression.
Jiawei Zhang, Jiawei Zhang, Yinan Wu, Yinan Wu, Jiayi Mu, Dijia Xin, Luyao Wang, Yili Fan, Suzhan Zhang, Yang Xu, Yang Xu   +10 more
doaj   +1 more source

High glycosyltransferase 8 domain containing two protein levels contribute to poor prognosis in urothelial carcinoma

, 2021
[[abstract]]Objective To examine the expression levels of the glycosyltransferase 8 domain containing protein 2 and its clinical implications in urothelial carcinoma patients.
Chen, TJ;Chan, TC;Li, CF;Dissanayaka, DDS;Kianpour, M;He, HL;Huang, SK;Li, WS;Chen, NY;Shiue, YL
core   +1 more source

Structures and mechanisms of glycosyltransferases [PDF]

Glycobiology, 2005
Glycosyltransferases (GTs) catalyze the transfer of a sugar moiety from an activated donor sugar onto saccharide and nonsaccharide acceptors. A sequence-based classification spreads GTs in many families thus reflecting the variety of molecules that can be used as acceptors.
Breton, C., Snajdrova, L., Jeanneau, C., Koca, J., Imberty, A.   +4 more
openaire   +2 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Moss cell walls: structure and biosynthesis

Frontiers in Plant Science, 2012
The genome sequence of the moss Physcomitrella patens has stimulated new research examining the cell wall polysaccharides of mosses and the glycosyltransferases that synthesize them as a means to understand fundamental processes of cell wall biosynthesis
Alison W. Roberts, Eric M. Roberts, Candace H. Haigler   +2 more
doaj   +1 more source

Landscape of prognosis and immunotherapy responsiveness under tumor glycosylation-related lncRNA patterns in breast cancer

Frontiers in Immunology, 2022
Aberrant glycosylation, a post-translational modification of proteins, is regarded to engage in tumorigenesis and malignant progression of breast cancer (BC).
Wenchang Lv, Yufang Tan, Xiaomei Zhou, Qi Zhang, Jun Zhang, Yiping Wu   +5 more
doaj   +1 more source