This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han +6 more
wiley +1 more source
Advances and challenges in plant N-glycoengineering: when fucosylation matters. [PDF]
Gauba K, Kunnummel V, Castilho A.
europepmc +1 more source
Genomic and Transcriptomic Insights Into Salinity Tolerance in Dry Pea
ABSTRACT Salinity is a major crop production constraint in dry pea (Pisum sativum L.), making the development of salt‐tolerant varieties essential to improve crop productivity and land‐use efficiency. The genetic mechanisms of salt tolerance in dry pea are largely unknown, and research on salt‐tolerant genes is limited.
Shailesh Raj Acharya +11 more
wiley +1 more source
Multi-omics analyses of Dracocephalum moldavica L. reveal two flavonoid glycosyltransferases in tilianin biosynthesis. [PDF]
Zhao Q, Zhang X, Wang W, Yu H, Wang Z.
europepmc +1 more source
Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque +4 more
wiley +1 more source
The dynamics of glycosylation in trophoblast cells: development, function, and pregnancy-related disorders. [PDF]
Wang T, Wang Y, Wu Y, Zhang Y, Ma F.
europepmc +1 more source
Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer
This study performed whole‐exome sequencing, proteomic, and phosphoproteomic analysis on 80 pairs of tumor tissues and matched normal adjacent tissues from colorectal cancer patients. The integrated proteogenomic study provides a comprehensive and nuanced understanding of the molecular heterogeneity between left‐ and right‐sided colorectal cancer ...
An Huang +11 more
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Creation of bioactive non-natural flavonoids via combinatorial prenylation-glycosylation cascades. [PDF]
Zhang H, Zhang A, Ji J, Yin WB.
europepmc +1 more source
A Near Telomere-to-Telomere Genome of Belamcanda chinensis Provides Insights Into Genome Evolution and the Biosynthesis of Characteristic Isoflavones. [PDF]
ABSTRACT Belamcanda chinensis is a non‐leguminous medicinal plant rich in bioactive isoflavones; however, the lack of a high‐quality reference genome has limited elucidation of its isoflavone biosynthetic and modification network. Here, we present the first near telomere‐to‐telomere genome assembly of B.
Wang YY +10 more
europepmc +2 more sources
This review summarizes how active constituents derived from Chinese herbal medicine exert anti‐tuberculosis (TB) effects via immunomodulation, direct inhibition of pathogens, and antioxidant activity. This synergistic, multi‐pathway mechanism highlights their potential as promising therapeutic candidates and adjunctive treatments against drug‐resistant
Qianqian Zhang +8 more
wiley +1 more source

