Results 171 to 180 of about 22,975 (220)

Glycosyltransferases and their Assays

ChemBioChem, 2010
AbstractGlycosyltransferases (GTs) are a large family of enzymes that are essential in all domains of life for the biosynthesis of complex carbohydrates and glycoconjugates. GTs catalyse the transfer of a sugar from a glycosyl donor to a variety of acceptor molecules, for example, oligosaccharides, peptides, lipids or small molecules.
Gerd K. Wagner, Thomas Pesnot
exaly   +3 more sources

Glycoconjugate glycosyltransferases

Glycoconjugate Journal, 2008
Assay methods for representative glycosyltransferases were described, covering those involved in the synthesis of glycosphingolipids, N-glycans, O-glycans, and proteoglycan glycosaminoglycans. In addition, intracellular localization of glycosyltransferase was comprehensively summarized.
Koichi, Furukawa, Akiko, Tsuchida, Tetsuya, Okajima, Keiko, Furukawa   +3 more
openaire   +2 more sources

Antibiotic glycosyltransferases

Biochemical Society Transactions, 2003
In the biosynthesis of several classes of antibiotics, sugars are attached to aglycone scaffolds by antibiotic-specific glycosyltransferases in the latter stages of the pathways. Two glycosylation pathways will be examined: the glycopeptide antibiotics of the vancomycin class and the aminocoumarin antibiotics of the novobiocin class.
C T, Walsh, H C, Losey, C L, Freel Meyers   +2 more
openaire   +2 more sources

GLYCOSYLTRANSFERASES IN OLIGOSACCHARIDE SYNTHESIS

Journal of Carbohydrate Chemistry, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiangping Qiam, Keiko Sujino, Monica M. Palcic, R. Murray Ratcliffe   +3 more
openaire   +1 more source

Glycosyltransferases as biocatalysts

Current Opinion in Chemical Biology, 2011
Glycosyltransferases are useful synthetic tools for the preparation of natural oligosaccharides, glycoconjugates and their analogues. High expression levels of recombinant enzymes have allowed their use in multi-step reactions, on mg to multi-gram scales.
openaire   +2 more sources

Iminosugars as glycosyltransferase inhibitors

Organic & Biomolecular Chemistry, 2021
The review describes the syntheses and inhibition properties of pyrrolidine, piperidine, azepane, pyrrolizidine and indolizidine iminosugars, as well as iminosugar nucleotides and iminodi- and -oligosaccharides.
Irene Conforti, Alberto Marra
openaire   +2 more sources

Engineering of glycosidases and glycosyltransferases

Current Opinion in Chemical Biology, 2006
In recent years, substantial advances have been made in the engineering of glycosidases and glycosyltransferases for the synthesis and degradation of glycan structures. Key developments include improvement of the thermostability of xylanase through comprehensive saturation mutagenesis, creation of the first glycosynthase derived from an inverting ...
Susan M, Hancock, Mark D, Vaughan, Stephen G, Withers   +2 more
openaire   +2 more sources

Glycosyltransferases, glycosylation and atherosclerosis

Glycoconjugate Journal, 2014
Cardiovascular diseases arising from atherosclerosis are currently the leading cause of mortality worldwide. Leukocyte recruitment is a key step for the successful initiation of atherosclerosis and occurs predominantly in the inflamed endothelium. Leukocyte recruitment is mediated by a group of adhesive molecules and chemokine receptors, which are ...
Chao Yu, Qiang-Hong Pu
exaly   +3 more sources

Glycosyltransferase structure and mechanism

Current Opinion in Structural Biology, 2000
The high-resolution X-ray crystal structures of a new form of bacteriophage T4 beta-glucosyltransferase, Escherichia coli MurG, Bacillus subtilis SpsA, bovine beta-1,4-galactosyltransferase 1 and rabbit N-acetylglucosaminyltransferase I have now been solved.
U M, Unligil, J M, Rini
openaire   +2 more sources

Molecular Modeling of Glycosyltransferases

2006
Glycosyltransferases, the enzymes that build oligosaccharides and glycoconjugates, have received much interest in recent years owing to their biological functions and their potential uses in biotechnology. The analysis of the wealth of sequences that are now available in databases allowed the classification in different families characterized by ...
Imberty, A., Wimmerova, M., Koca, J., Breton, C.   +3 more
openaire   +2 more sources