Results 11 to 20 of about 9,814 (162)

Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]

, 2019
The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T., Jin, Seongeon, Kim, Sangpil, Ryu, Ja-Hyoung   +3 more
core   +1 more source

Circular dichroism spectroscopic detection of ligand binding induced subdomain IB specific structural adjustment of human serum albumin [PDF]

, 2013
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein.
Beaven G. H., Bertucci C., Bertucci C., Bhattacharya A. A., Brock A., Buttar D., Carter D. C., Curry S., Curry S., Datta P., Dockal M., Farruggia B., Fehske K. J., Fehske K. J., Fehske K. J., Ferenc Zsila, Ghuman J., Ishida S., Koide M., Kragh-Hansen U., Krenzel E. S., Plager J. E., Ryan A. J., Ryan A. J., Sengupta A., Shi D., Simard J. R., Sjöholm I., Strickland E. H., Sudlow G., Sudlow G., Takikawa H., Wanwimolruk S., Zhu L., Zsila F., Zsila F., Zunszain P. A., Zunszain P. A.   +37 more
core   +1 more source

Cx43 and mechanotransduction in bone [PDF]

, 2015
Bone adaptation to changes in mechanical stimuli occurs by adjusting bone formation and resorption by osteoblasts and osteoclasts, to maintain optimal bone mass.
Donahue, Henry J., Plotkin, Lilian I., Speacht, Toni L.   +2 more
core   +1 more source

Endothelium-derived Hyperpolarizing Factor (EDHF) Mediates Endothelium-dependent Vasodilator Effects of Aqueous Extracts from Eucommia ulmoides Oliv. Leaves in Rat Mesenteric Resistance Arteries [PDF]

, 2008
The vascular effects of an aqueous extract prepared from the leaves of Eucommia ulmoides Oliv. (ELE), a medicinal herb commonly used in antihypertensive herbal prescriptions in China, were investigated in rat mesenteric resistance arteries.
Jin, Xin, Kawamura, Naomi, Kawasaki, Hiromu, Otonashi-Satoh, Yukiko, Sun, Pengyuan, Tsuboi, Takashi, Ueda, Taro, Yamaguchi, Yasuyo   +7 more
core   +1 more source

1,2,5-Oxadiazolo[3,4-b]glycyrrhetinic acid [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
THE TITLE COMPOUND [SYSTEMATIC NAME: 11-oxo-2,3-(oxy-dinitrilo)olean-12-en-29-oic acid], C(30)H(42)N(2)O(4), contains a linear array of five six-membered rings and a five-membered heterocyclic ring. The C ring, containing an α,β-unsaturated ketone, has a slightly distorted half-chair conformation, as does the A ring, with N-C-C angles 125.3 (5), 111.2 (
Jun Hu, Libing Yu, Ruji Wang, Yong Ju
openaire   +3 more sources

Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan, Anna K. McClain, Andrea Trementozzi, Sogu Sohn, Lingxia Qiao, Chi Zhao, Padmini Rangamani, Jeanne C. Stachowiak, Janet Zoldan   +8 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

A review of the health effects and uses of drugs of plant licorice (Glycyrrhiza glabra L.) in Iran [PDF]

, 2014
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Bahmani, Mahmoud., Delfan, Bahram., Eftekhari, Zohre., Forouzan, Shirin., Jeloudari, Mahyar., Rafieian-Kopaei, Mahmoud., Zargaran, Arman.   +6 more
core   +2 more sources

Nanofiber PVA‐Based Membranes Incorporating Functionalized Spanish Broom Derivatives for Sustainable Water Purification

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study investigates Spanish broom (Spartium junceum) as a renewable source for electrospun composite membranes in sustainable water purification. MCC and biochar were functionalized with eco‐friendly precursors and nanomaterials (i.e., HNT, β‐CDs) to develop hybrid PVA nanofiber composites.
Giulia Rando, Silvia Sfameni, Jozefien Geltmeyer, Alessandra Palella, Lorenzo Spadaro, Alberto Riminucci, Karen De Clerck, Maria Rosaria Plutino   +7 more
wiley   +1 more source

Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]

, 2018
Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita, Parija, Subas Chandra, Rattan, Satish, Suklabaidya, Sujit   +3 more
core   +2 more sources