Results 21 to 30 of about 6,171 (143)

Evidence for Anti-Inflammatory Activity of Isoliquiritigenin, 18β Glycyrrhetinic Acid, Ursolic Acid, and the Traditional Chinese Medicine Plants Glycyrrhiza glabra and Eriobotrya japonica, at the Molecular Level

Medicines, 2019
Background: We investigated the effect of root extracts from the traditional Chinese medicine (TCM) plants Glycyrrhiza glabra L., Paeonia lactiflora Pall., and the leaf extract of Eriobotrya japonica (Thunb.) Lindl., and their six major secondary ...
Jun-Xian Zhou, Michael Wink
doaj   +1 more source

Identification of potential anti-pneumonia pharmacological components of Glycyrrhizae Radix et Rhizoma after the treatment with Gan An He Ji oral liquid

Journal of Pharmaceutical Analysis, 2022
Glycyrrhizae Radix et Rhizoma, a traditional Chinese medicine also known as Gan Cao (GC), is frequently included in clinical prescriptions for the treatment of pneumonia.
Xiaojuan Jiang, Yihua Lin, Yunlong Wu, Caixia Yuan, Xuli Lang, Jiayun Chen, Chunyan Zhu, Xinyi Yang, Yu Huang, Hao Wang, Caisheng Wu   +10 more
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Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug

The Scientific World Journal, 2013
The triblock 18β-glycyrrhetinic acid-poly(ethylene glycol)-18β-glycyrrhetinic acid conjugates (GA-PEG-GA) based self-assembled micelles were synthesized and characterized by FTIR, NMR, transmission electron microscopy, and particle size analysis.
Fengbo Wu, Ting Xu, Chi Liu, Can Chen, Xiangrong Song, Yu Zheng, Gu He   +6 more
doaj   +1 more source

Enhancement of the Bioavailability and Anti-Inflammatory Activity of Glycyrrhetinic Acid via Novel Soluplus^®—A Glycyrrhetinic Acid Solid Dispersion

Pharmaceutics, 2022
Glycyrrhetinic acid (GA) is an anti-inflammatory drug with potential for development. However, the poor solubility of GA in water leads to extremely low bioavailability, which limits its clinical applications.
Hao Wang, Runwei Li, Yuan Rao, Saixing Liu, Chunhui Hu, Yong Zhang, Linchao Meng, Qilin Wu, Qiuhong Ouyang, Hao Liang, Meng Qin   +10 more
doaj   +1 more source

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives

Molecules, 2019
A series of new glycyrrhetinic acid derivatives was synthesized via the opening of its ring A along with the coupling of an amino acid. The antiproliferative activity of the derivatives was evaluated against a panel of nine human cancer cell lines ...
Daniela P.S. Alho, Jorge A.R. Salvador, Marta Cascante, Silvia Marin   +3 more
doaj   +1 more source

Inhibition of human complement by β‐glycyrrhetinic acid [PDF]

Immunology, 1997
Licorice, the root extract of Glycyrrhiza glabra L., is used as a medicine for various diseases. Anti‐inflammatory as well as anti‐allergic activities have been attributed to one of its main constituents, glycyrrhizin. These activities are mainly ascribed to the action of the aglycone, β‐glycyrrhetinic acid.
Kroes, B. H., Beukelman, C. J., Van Den Berg, A. J.J., Wolbink, G. J., Van Dijk, H., Labadie, R. P.   +5 more
openaire   +5 more sources

Glycyrrhetinic Acid Reverses the Lipopolysaccharide-Induced Hypocontractility to Noradrenaline in Rat Aorta: Implications to Septic Shock

Journal of Pharmacological Sciences, 2014
.: Septic shock and associated vascular hyporeactivity to vasoconstrictor agonists remain a major problem of critical care medicine. Here we report that glycyrrhetinic acid (GA), the active component of licorice, effectively restores vascular ...
Bernard Muller, Petr G. Aparin, Jean-Claude Stoclet, Andrei L. Kleschyov   +3 more
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Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

Molecules, 2019
A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A.
Daniela P. S. Alho, Jorge A. R. Salvador, Marta Cascante, Silvia Marin   +3 more
doaj   +1 more source

Antimicrobial and Antioxidant Activities of 18β-Glycyrrhetinic Acid Biotransformed by Aspergillus niger

Microbiology Research
The search for novel plant-based antioxidant and antibacterial medication has garnered a lot of attention lately. Glycyrrhiza glabra, known as licorice, is one of the most important medicinal plants.
Shaymaa Wagdy El-Far, Mahmoud A. Al-Saman, Fatma I. Abou-Elazm, Rania Ibrahim Shebl, Asmaa Abdella   +4 more
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Development of a UPLC-TQ/MS Approach for the Determination of Eleven Bioactive Components in Haizao Yuhu Decoction Plus-Minus Haizao and Gancao Drug Combination after Oral Administration in a Rat Model of Hypothyroidism

Molecules, 2016
Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases.
Yingchang Ma, Yang Zhang, Yuanjuan Zhai, Zhenhua Zhu, Ying Pan, Dawei Qian, Shulan Su, Xinsheng Fan, Jinao Duan   +8 more
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