Results 21 to 30 of about 5,898,960 (197)

Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights

RSC Advances, 2021
Six compounds namely, tanshinone IIA (1), carnosic acid (2), rosmarinic acid (3), salvianolic acid B (4), baicalein (5), and glycyrrhetinic acid (6) were screened for their anti-SARS-CoV-2 activities against both the spike (S) and main protease (Mpro ...
Dalia Elebeedy, W. Elkhatib, A. Kandeil, Aml Ghanem, Omnia Kutkat, Radwan Alnajjar, M. Saleh, Ahmed I. Abd El Maksoud, Ingy Badawy, A. Al-karmalawy   +9 more
semanticscholar   +1 more source

Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy

Molecules, 2022
Liver cancer is one of the most common causes of cancer mortality worldwide. Chemotherapy and radiotherapy are the conventional therapies generally employed in patients with liver tumors.
A. Speciale, Claudia Muscarà, M. S. Molonia, M. Cristani, F. Cimino, A. Saija   +5 more
semanticscholar   +1 more source

18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs

Journal of Pharmaceutical Analysis, 2022
Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) is a natural compound that exists widely in herbal medicines,
Qian Zhang, Piao Luo, Liuhai Zheng, Jiayun Chen, Junzhe Zhang, Huan Tang, Dandan Liu, Xueling He, Qiaoli Shi, Liwei Gu, Jiahao Li, Qiuyan Guo, Chuanbin Yang, Y. Wong, Fei Xia, Jigang Wang   +15 more
semanticscholar   +1 more source

Efficient synthesis of piperazinyl amides of 18β-glycyrrhetinic acid

Beilstein Journal of Organic Chemistry, 2020
In the present study, a practical method to prepare piperazinyl amides of 18β-glycyrrhetinic acid was developed. Two main procedures for the construction of important intermediate 8 are discussed.
Dong Cai, ZhiHua Zhang, Yufan Meng, KaiLi Zhu, LiYi Chen, ChangXiang Yu, ChangWei Yu, ZiYi Fu, DianShen Yang, YiXia Gong   +9 more
doaj   +1 more source

Design, Synthesis, and Biological Activity of 18β-Glycyrrhetinic Acid Derivatives and Their Metal Complexes

Medical Sciences Forum, 2022
The increasing morbidity and mortality caused by infections with pathogenic bacteria (fungus or bacteria) have highlighted an urgent requirement for developing novel anti-bacterial agents to protect the health and integrity of human life.
Caiyun Yang, Xinhui Pan, Xiaoda Yang
doaj   +1 more source

Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

Acta Pharmaceutica Sinica B, 2019
Members of the RAS proto-oncogene superfamily are indispensable molecular switches that play critical roles in cell proliferation, differentiation, and cell survival.
Yuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Xueyan Hu, Jin Tao, Yuanyuan Hou, Gang Bai   +7 more
doaj   +1 more source

Database-aided UHPLC-Q-orbitrap MS/MS strategy putatively identifies 52 compounds from Wushicha Granule to propose anti-counterfeiting quality-markers for pharmacopoeia

Chinese Medicine, 2023
Wushicha Granule, an over-the-counter-drug (OTC) prescription, consists of 19 traditional Chinese herbals medicines (CHMs), such as Chaihu, Hongcha, Chuanxiong, Houpo, and Gancao.
Xican Li, Shaoman Chen, Jingyuan Zeng, Rongxin Cai, Yilan Liang, Chuanbin Chen, Ban Chen, Chunhou Li   +7 more
doaj   +1 more source

Synthesis, Antiviral, and Antibacterial Activity of the Glycyrrhizic Acid and Glycyrrhetinic Acid Derivatives

Russian journal of bioorganic chemistry, 2022
Glycyrrhizic acid and its primary metabolite glycyrrhetinic acid, are the main active ingredients in the licorice roots (glycyrrhiza species), which are widely used in several countries of the world, especially in east asian countries (China, Japan ...
E. A. Mohammed, Y. Peng, Z. Wang, X. Qiang, Q. Zhao   +4 more
semanticscholar   +1 more source

Hepatoprotective Effects of Glycyrrhetinic Acid on Lithocholic Acid-Induced Cholestatic Liver Injury Through Choleretic and Anti-Inflammatory Mechanisms

Frontiers in Pharmacology, 2022
Cholestasis is a clinical syndrome triggered by the accumulation and aggregation of bile acids by subsequent inflammatory responses. The present study investigated the protective effect of glycyrrhetinic acid (GA) on the cholestatic liver injury induced ...
Qian Wang, Guochao Song, Fengfeng Weng, Bin Zou, Jingyi Jin, Dong-Ming Yan, Bo Tan, Jing Zhao, Yue Li, F. Qiu   +9 more
semanticscholar   +1 more source

A SIMPLE AND RAPID METHOD FOR SIMULTANEOUS ESTIMATION OF GLYCYRRHETINIC ACID AND PIPERINE BY HPTLC IN A HERBOMINERAL FORMULATION [PDF]

Journal of Advanced Pharmaceutical Technology & Research, 2010
Many of the traditional herbal formulations contain extracts of Piper longum and Glycyrrhiza glabra, piperine and glycyrrhetinic acid respectively, being active constituents of these two herbs.
Ashish Trivedi, S. H. Mishra
doaj   +2 more sources