Results 61 to 70 of about 6,204 (162)

Synthesis and antiviral activities of spacer-linked 1-thioglucuronide analogues of glycyrrhizin

Beilstein Journal of Organic Chemistry, 2012
The influenza virus infection remains a significant threat to public health and the increase of antiviral resistance to available drugs generates an urgent need for new antiviral compounds.
Christian Stanetty, Andrea Wolkerstorfer, Hassan Amer, Andreas Hofinger, Ulrich Jordis, Dirk Claßen-Houben, Paul Kosma   +6 more
doaj   +1 more source

Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species

Journal of Advanced Research, 2015
Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and as sweetener in the food industry.
Mohamed A. Farag, Andrea Porzel, Ludger A. Wessjohann   +2 more
doaj   +1 more source

The role of gap junctions composed of connexin 43 on the anti-tumor effect induced by etoposide

Zhongguo aizheng zazhi, 2015
Background and purpose: Gap junctions(GJ) could enhance cytotoxicity induced by chemotherapeutic agents. However, whether or not GJ composed of connexin 43 (Cx43) could increase etoposide cytotoxicity remains unclear. The aim of this study was to explore
汪灵芝, 彭建新
doaj  

Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice

Frontiers in Physiology, 2018
Development of spider veins is caused by the remodeling of veins located in the upper dermis and promoted by risk factors such as obesity or pregnancy that chronically increase venous pressure.
Hanna Kuk, Caroline Arnold, Andreas H. Wagner, Markus Hecker, Carsten Sticht, Thomas Korff, Thomas Korff   +6 more
doaj   +1 more source

(3β,18β,20β)-N-Ethoxycarbonylmethyl-3-nitrato-11-oxoolean-12-ene-29-carboxamide methanol monosolvate

Acta Crystallographica Section E, 2012
The title compound, C34H52N2O7·CH4O, is the methanol solvate of a difunctionalized derivative of the therapeutic agent 18β-glycyrrhetinic acid, a pentacyclic triterpene. The five six-membered rings of the glycyrrhetinic acid moiety show
Laszlo Czollner, Ulrich Jordis, Kurt Mereiter   +2 more
doaj   +1 more source

Liver-Targeted Combination Therapy Basing on Glycyrrhizic Acid-Modified DSPE-PEG-PEI Nanoparticles for Co-delivery of Doxorubicin and Bcl-2 siRNA

Frontiers in Pharmacology, 2019
Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms.
Guixiang Tian, Ruiyan Pan, Bo Zhang, Meihua Qu, Bo Lian, Hong Jiang, Zhiqin Gao, Jingliang Wu   +7 more
doaj   +1 more source

Outcomes in patients with nonerosive reflux disease treated with a proton pump inhibitor and alginic acid ± glycyrrhetinic acid and anthocyanosides

Clinical and Experimental Gastroenterology, 2013
Francesco Di Pierro,1 Mario Gatti,2 Giuliana Rapacioli,3 Leandro Ivaldi4 1Velleja Research, Milan, 2Gastroenterology Department, Giussano Hospital, Monza-Brianza, 3AIOR, Piacenza, 4Digestive Endoscopic Department, Ceva Hospital, Ceva, Cuneo, Italy ...
Di Pierro F, Gatti M, Rapacioli G, Ivaldi L   +3 more
doaj  

Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells [Retraction]

Drug Design, Development and Therapy, 2014
Cheng M, Xu H, Wang Y, et al. Drug Des Devel Ther. 2013;7:1287–1299. It has come to the notice of this journal that the published paper:Cheng M, Xu H, Wang Y, et al.
Cheng M, Xu H, Wang Y, Chen H, He B, Gao X, Li Y, Han J, Zhang Z   +8 more
doaj  

Pharmacological underlying mechanisms of the anticancer effect of licorice: Bioinformatics and experimental verification

Journal of Holistic Integrative Pharmacy
Purpose: Cancer is the second leading cause of human mortality and has rapidly become a major global issue. According to traditional Chinese medicine (TCM) theory, the primary pathogenesis of cancer is the deficiency of ''vital Qi''.
Mengqi Liu, Lingping Fu, Hao Fu, Yu Chen, Mengxia Wu, Hanchun Liu   +5 more
doaj   +1 more source

Discovery of a novel broad-spectrum inhibitor against influenza virus A

Virology Journal
The pandemic of influenza A virus (IAV) is on the rise worldwide, however, drug resistance to anti-influenza drugs has been widely found. The viral mutation of IAV highlights the necessitate for discovery of new antiviral agents with broad-spectrum ...
Ran Yu, Peng Li, Rong Shen, Wenting Fei
doaj   +1 more source